INT144840

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 3.13
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna4)
Anatomy Link Frequency
neurons 2
TMJ 2
Kcna4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 7 100.00 Very High Very High Very High
Inflammation 5 99.98 Very High Very High Very High
intrathecal 1 99.84 Very High Very High Very High
Snapping jaw 10 99.72 Very High Very High Very High
Adelta 1 98.48 Very High Very High Very High
trigeminal ganglion 4 98.00 Very High Very High Very High
Spinal nerve ligature 1 95.84 Very High Very High Very High
allodynia 3 95.48 Very High Very High Very High
Neuropathic pain 2 94.28 High High
Spinal cord 1 87.08 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 100.00 Very High Very High Very High
INFLAMMATION 5 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 10 99.72 Very High Very High Very High
Hypersensitivity 3 96.40 Very High Very High Very High
Neuropathic Pain 5 95.48 Very High Very High Very High
Nociception 2 90.96 High High
Pain 4 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After Kv3.4 or Kv4.3 expression in lumbar DRG neurons was suppressed by intrathecal injections of antisense oligodeoxynucleotides, mechanical but not thermal hypersensitivity developed.
Negative_regulation (suppressed) of Gene_expression (expression) of Kv4 in neurons associated with dorsal root ganglion, hypersensitivity and intrathecal
1) Confidence 0.55 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.21 Pain Relevance 1.03
These findings suggest that TMJ inflammation reduces the expression of Kv1.4 subunits in the small-/medium sized (Adelta-/C-) TRG neurons and this may contribute to trigeminal inflammatory allodynia in TMJ disorder.
Negative_regulation (reduces) of Gene_expression (expression) of Kv1.4 in TMJ associated with snapping jaw, allodynia, inflammation, trigeminal ganglion and adelta
2) Confidence 0.41 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17584507 Disease Relevance 1.92 Pain Relevance 1.57

General Comments

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