INT14486

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 11.24
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
cerebrospinal fluid 5
antibody secreting cells 2
Optic 2
blood 1
striatum 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 80 99.86 Very High Very High Very High
Neuritis 41 99.40 Very High Very High Very High
Inflammation 25 97.84 Very High Very High Very High
Potency 2 97.24 Very High Very High Very High
intrathecal 5 96.56 Very High Very High Very High
headache 6 94.72 High High
Central nervous system 43 94.32 High High
Spinal cord 18 94.28 High High
IPN 1 87.64 High High
Neuropeptide 3 87.32 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 77 99.86 Very High Very High Very High
Neurological Disease 14 99.68 Very High Very High Very High
Optic Neuritis 41 99.40 Very High Very High Very High
Pressure Volume 2 Under Development 55 99.02 Very High Very High Very High
INFLAMMATION 25 97.84 Very High Very High Very High
Disease 12 94.96 High High
Headache 3 94.72 High High
Heart Rate Under Development 6 93.76 High High
Inflammatory Pain 1 87.64 High High
Autoimmune Disease 16 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of the HLA system in anti-MBP antibody production in ON was investigated employing a restriction fragment length polymorphism system for genomic HLA-DQ and -DR typing and an immunospot assay for the detection of individual cells secreting antibodies to three different synthetic MBP peptides.
Localization (secreting) of MBP associated with neuritis
1) Confidence 0.74 Published 1994 Journal Scand. J. Immunol. Section Abstract Doc Link 7516573 Disease Relevance 1.09 Pain Relevance 0.78
KEY RESULTS: In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR.
Localization (decrease) of MBP
2) Confidence 0.74 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20105178 Disease Relevance 0.08 Pain Relevance 0
When BN 52021 (20 mg/kg i.v.) was injected immediately after bupivacaine (2 mg/kg), a partial reversion of the decrease of MBP and HR was observed, whereas the dose of 10 mg/kg was ineffective.
Localization (decrease) of MBP
3) Confidence 0.73 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2594614 Disease Relevance 0.08 Pain Relevance 0.11
Thirty-two out of 40 patients (80%) with ON had cells in cerebrospinal fluid secreting anti-MBP peptide antibodies while this occurred in 10/19 patients with other neurological diseases (53%; mainly in patients with inflammatory diseases in the central nervous system).
Localization (secreting) of anti-MBP peptide in cerebrospinal fluid associated with neurological disease, inflammation, central nervous system, disease and neuritis
4) Confidence 0.69 Published 1994 Journal Scand. J. Immunol. Section Abstract Doc Link 7516573 Disease Relevance 1.10 Pain Relevance 0.78
To investigate improvement effects on OH, the dose of phenylephrine without influence on resting MBP in both unstressed and SART-stressed rats was determined as 1 ?
Localization (resting) of MBP associated with pressure volume 2 under development
5) Confidence 0.65 Published 2010 Journal Biopsychosoc Med Section Body Doc Link PMC2967492 Disease Relevance 1.29 Pain Relevance 0
Sections were then incubated overnight at 4°C with mouse monoclonal antibodies directed against CD11b/CD11c (OX42), MHC class II molecules (OX6) or myelin basic protein.
Localization (directed) of myelin basic protein
6) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.14 Pain Relevance 0.03
Optic neuritis and multiple sclerosis: anti-MBP and anti-MBP peptide antibody-secreting cells are accumulated in CSF.
Localization (secreting) of MBP in Optic associated with multiple sclerosis, optic neuritis and neuritis
7) Confidence 0.62 Published 1993 Journal Neurology Section Title Doc Link 7513391 Disease Relevance 1.08 Pain Relevance 0.81
For quantification of axons and myelinating oligodendrocytes, NF-H, CNPase, MBP, and Bielschowsky and Luxol fast blue positive areas were digitized throughout the peri-infarct corpus callosum and striatum, as well as the contralateral homologous area.
Localization (digitized) of MBP in striatum
8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0 Pain Relevance 0
RESULTS: Cerebrospinal fluid cells that secreted anti-MBP or anti-PLP antibodies were detected in 10 of 15 and in 21 of 23 patients with acute ON, while they were detected in nine of 18 and in six of 18 patients with other neurological diseases, respectively.
Localization (secreted) of MBP in Cerebrospinal fluid
9) Confidence 0.59 Published 1994 Journal Arch. Neurol. Section Body Doc Link 7524468 Disease Relevance 0.07 Pain Relevance 0
Optic neuritis and multiple sclerosis: anti-MBP and anti-MBP peptide antibody-secreting cells are accumulated in CSF.
Localization (secreting) of MBP in Optic associated with multiple sclerosis, optic neuritis and neuritis
10) Confidence 0.58 Published 1993 Journal Neurology Section Title Doc Link 7513391 Disease Relevance 1.08 Pain Relevance 0.81
There were cells secreting IgG antibodies to MBP and the four peptides in blood at mean numbers of 0.9 to 4.6 per 10(5) mononuclear cells, without differences between the three patient groups.
Localization (secreting) of MBP in mononuclear cells
11) Confidence 0.58 Published 1993 Journal Neurology Section Abstract Doc Link 7513391 Disease Relevance 1.06 Pain Relevance 0.80
Similar results were obtained if MP was applied to cultures that were not stimulated with MBP (spontaneous ex vivo release, data not shown), thus further fortifying the observation about the potency of MP in down-regulation of IL-17 and IFN-?
Localization (release) of MBP associated with potency
12) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.24 Pain Relevance 0.18
No difference was observed for anti-MBP-secreting cells.
Localization (secreting) of MBP
13) Confidence 0.52 Published 1994 Journal Arch. Neurol. Section Body Doc Link 7524468 Disease Relevance 0.06 Pain Relevance 0
MAIN OUTCOME MEASURES: Numbers of anti-MBP and anti-PLP antibody-secreting cells in peripheral blood and cerebrospinal fluid samples that were enumerated with an immunospot assay.
Localization (secreting) of MBP in cerebrospinal fluid
14) Confidence 0.52 Published 1994 Journal Arch. Neurol. Section Body Doc Link 7524468 Disease Relevance 0.08 Pain Relevance 0
At 30 minutes afterincision, MBP and DBP returned to basal levels in the DEX group, whereas the variables were significantly lower in the REM group.
Localization (returned) of MBP
15) Confidence 0.48 Published 2007 Journal J Clin Anesth Section Body Doc Link 17572323 Disease Relevance 0 Pain Relevance 0
Anti-myelin basic protein and anti-proteolipid protein antibody-secreting cells in the cerebrospinal fluid of patients with acute optic neuritis.
Localization (secreting) of Anti-myelin basic protein in cerebrospinal fluid associated with optic neuritis and neuritis
16) Confidence 0.45 Published 1994 Journal Arch. Neurol. Section Title Doc Link 7524468 Disease Relevance 0.10 Pain Relevance 0.19
For quantification of axons and myelinating oligodendrocytes, NF-H, CNPase, MBP, and Bielschowsky and Luxol fast blue positive areas were digitized throughout the peri-infarct corpus callosum and striatum, as well as the contralateral homologous area.
Localization (digitized) of MBP in corpus callosum
17) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0 Pain Relevance 0
in the MBP-TRPV4-Ct complex, both in presence and absence of Ca2+.
Localization (absence) of MBP
18) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.39 Pain Relevance 0.27
MAIN OUTCOME MEASURES: Numbers of anti-MBP and anti-PLP antibody-secreting cells in peripheral blood and cerebrospinal fluid samples that were enumerated with an immunospot assay.
Localization (secreting) of MBP in blood
19) Confidence 0.18 Published 1994 Journal Arch. Neurol. Section Body Doc Link 7524468 Disease Relevance 0.08 Pain Relevance 0
In blood from MS and OIND patients, anti-MBP IgG antibody secreting cells were detected infrequently and at low numbers.
Localization (secreting) of MBP in antibody secreting cells associated with multiple sclerosis and neurological disease
20) Confidence 0.16 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 1695639 Disease Relevance 1.11 Pain Relevance 0.46

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