INT144862

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
epithelial cells 1
Tlr4 (Mus musculus)
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 99.62 Very High Very High Very High
Inflammatory mediators 11 81.72 Quite High
Inflammation 16 75.80 Quite High
Inflammatory response 9 44.64 Quite Low
chemokine 9 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 81.32 Quite High
Cv General 2 Under Development 1 75.00 Quite High
Fever 2 53.04 Quite High
Chlamydia Infection 24 8.24 Low Low
Infection 5 5.00 Very Low Very Low Very Low
Bacterial Infection 3 5.00 Very Low Very Low Very Low
Reprotox - General 3 3 5.00 Very Low Very Low Very Low
Peritonitis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epithelial cell IL-6, CXCL1 and CCL20 responses were evident following LPS treatment, compared with epithelial cells in control media, by 6 h (Fig. 6E–G) but an increase in PGE concentration in response to LPS was only detected at 30 h (Fig. 6H).


LPS Positive_regulation (increase) of PGE in epithelial cells
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.23 Pain Relevance 0.11
SC-560 and acetaminophen did not alter the LPS-induced PGE(2) and T(c) rises; MK-0663 prevented both the late PGE(2) and T(c) rises.
LPS Positive_regulation (induced) of PGE associated with paracetamol
2) Confidence 0.01 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17584956 Disease Relevance 0.13 Pain Relevance 0.17

General Comments

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