INT144868

Context Info Confidence 0.62 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.23 Pain Relevance 0.29

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat) Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)

Anatomy Link Frequency Lung 2 skeletal muscles 1 A549 1 Cat (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 112 85.84 Analgesic 2 80.88 Inflammation 40 59.00 chemokine 6 54.24 cytokine 17 5.00 metalloproteinase 12 5.00 anesthesia 3 5.00 ketamine 2 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Pulmonary Disease 4 98.88 Adenocarcinoma 1 98.44 Stress 27 97.00 Pulmonary Fibrosis 58 85.84 Leukemia 1 85.72 Infection 2 84.04 Pox Virus Infection 1 79.40 Apoptosis 5 70.00 INFLAMMATION 34 59.00 Lung Injury 7 54.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whole lung catalase mRNA expression was significantly decreased at 7 and 14 days after intratracheal bleomycin administration compared with controls (p < 0.01, respectively) (Figure 3B).

Transcription (expression) of lung catalase in lung

1) Confidence 0.62 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.31 Pain Relevance 0.15

Lung catalase and glutathione peroxidase activity

Transcription (activity) of Lung catalase in Lung

2) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.15 Pain Relevance 0.06

Neurotropin enhanced mRNA expression of the redox-regulating molecules, glutathione peroxidase and catalase and, particularly, TRX, in human lung adenocarcinoma A549 cells.

Transcription (expression) of catalase in A549 associated with adenocarcinoma

3) Confidence 0.14 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17585112 Disease Relevance 0.76 Pain Relevance 0.08

This analysis was performed as described [12] to measure MAFbx/atrogin-1, MuRF1, iNos, superoxide dismutases (Sod-1, Sod-2, Sod-3) and catalase (Cat) mRNA expression in skeletal muscles and in cultured C2C12 myoblasts.

Transcription (expression) of catalase in skeletal muscles

4) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0 Pain Relevance 0

General Comments

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