INT144881

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.60
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (BCL6) nucleolus (BCL6) nucleus (BCL6)
intracellular (BCL6)
Anatomy Link Frequency
B-cell 4
BCL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 99.68 Very High Very High Very High
Inflammatory response 3 96.60 Very High Very High Very High
Inflammation 18 86.16 High High
lidocaine 8 50.00 Quite Low
cytokine 3 33.32 Quite Low
Arthritis 1 28.44 Quite Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Cauda equina syndrome 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 98.20 Very High Very High Very High
INFLAMMATION 20 96.24 Very High Very High Very High
Lymphatic System Cancer 205 82.72 Quite High
Diffuse Large B-cell Lymphoma 68 80.72 Quite High
Cancer 113 72.40 Quite High
Apoptosis 15 67.56 Quite High
Repression 4 64.24 Quite High
Disease 34 63.08 Quite High
Genetic Translocation 2 52.80 Quite High
Mantle-cell Lymphoma 33 52.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the observation that B-cell lymphoma-2 protein overexpression or the lack of caspase 9 abolished apoptosis clearly implicates the intrinsic mitochondrial death pathway in lidocaine-induced apoptosis.


Positive_regulation (overexpression) of Gene_expression (overexpression) of B-cell lymphoma-2 protein in B-cell
1) Confidence 0.43 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0 Pain Relevance 0
Apoptosis by lidocaine was strongly reduced by B-cell lymphoma-2 protein overexpression or caspase-9 deficiency, whereas cells lacking the death receptor pathway components caspase 8 and Fas-associated protein with death domain were not protected and displayed similar apoptotic alterations as the parental cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B-cell lymphoma-2 protein in B-cell
2) Confidence 0.31 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.07 Pain Relevance 0
One hundred forty-nine of 163 DLBCLs could then be classified into GCB group (pattern A), activated GCB group (pattern B), and activated non-GCB group (pattern C) according to the expression of CD10, BCL6, MUM1, and CD138.
Positive_regulation (according) of Gene_expression (expression) of BCL6
3) Confidence 0.18 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.47 Pain Relevance 0
This lack of correlation has been reported previously21 and suggests that rearrangement of the Bcl-6 gene does not directly lead to Bcl-6 protein expression in every case.
Neg (not) Positive_regulation (lead) of Gene_expression (expression) of Bcl-6 protein
4) Confidence 0.17 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.46 Pain Relevance 0
on the expression of Bcl-6 target genes since it also leads to release the
Positive_regulation (leads) of Gene_expression (expression) of Bcl-6
5) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.60 Pain Relevance 0.18

General Comments

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