INT144882

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (BCL6) nucleolus (BCL6) nucleus (BCL6)
intracellular (BCL6)
Anatomy Link Frequency
B-cell 2
BCL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 50.00 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Cauda equina syndrome 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 166 96.40 Very High Very High Very High
Disease 20 70.52 Quite High
Diffuse Large B-cell Lymphoma 24 69.44 Quite High
Death 11 50.00 Quite Low
Apoptosis 4 50.00 Quite Low
Cancer 44 38.56 Quite Low
Congenital Anomalies 2 29.08 Quite Low
Carcinoma 8 15.84 Low Low
Adenocarcinoma 6 6.72 Low Low
Breast Cancer 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the observation that B-cell lymphoma-2 protein overexpression or the lack of caspase 9 abolished apoptosis clearly implicates the intrinsic mitochondrial death pathway in lidocaine-induced apoptosis.


Negative_regulation (abolished) of Gene_expression (overexpression) of B-cell lymphoma-2 protein in B-cell
1) Confidence 0.26 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0 Pain Relevance 0
Although not statistically significant, it is consistent with recent observations, using gene expression and microarray technology, that Bcl-6 expression and GC differentiation are favorable prognostic factors.21 It is of particular interest that a significant proportion (32%) of the cases with a Bcl-6 gene rearrangement lacked expression of Bcl-6 protein using immunocytochemistry.
Negative_regulation (lacked) of Neg (lacked) Gene_expression (expression) of Bcl-6 protein
2) Confidence 0.14 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.45 Pain Relevance 0
In this study, we used immunohistochemistry to define Bcl-2 and Bcl-6 expression.
Negative_regulation (define) of Gene_expression (expression) of Bcl-6
3) Confidence 0.10 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.48 Pain Relevance 0

General Comments

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