INT144885

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.89
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (AMELX) signal transduction (AMELX) extracellular region (AMELX)
cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
AMELX (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.28 Very High Very High Very High
Potency 1 92.08 High High
Crohn's disease 2 83.08 Quite High
Inflammation 8 80.00 Quite High
qutenza 1 46.72 Quite Low
Thermal hyperalgesia 1 40.72 Quite Low
Analgesic 3 25.00 Low Low
Lasting pain 1 25.00 Low Low
corticosteroid 2 24.56 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 338 100.00 Very High Very High Very High
Infertility 5 99.04 Very High Very High Very High
Biliary Liver Cirrhosis 16 96.40 Very High Very High Very High
Disease 74 92.24 High High
Liver Disease 18 88.72 High High
Inflammatory Bowel Disease 6 87.92 High High
Primary Sclerosing Cholangitis 14 85.04 High High
Death 8 82.08 Quite High
INFLAMMATION 8 77.88 Quite High
Hepatitis 36 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the previously reported clinical candidate, AMG 517 (compound 1), a series of related piperazinylpyrimidine analogues were synthesized and evaluated as antagonists of the vanilloid 1 receptor (VR1 or TRPV1).
Gene_expression (synthesized) of AMG associated with antagonist
1) Confidence 0.11 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17585751 Disease Relevance 0 Pain Relevance 0.17
AIH is not covered by health insurance, and costs about 20,000 yen (around 175 US dollars).
Neg (not) Gene_expression (covered) of AIH
2) Confidence 0.06 Published 2006 Journal BMC Med Ethics Section Body Doc Link PMC1481581 Disease Relevance 0.18 Pain Relevance 0
Classification of AIH
Gene_expression (Classification) of AIH associated with autoimmune hepatitis
3) Confidence 0.05 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.09 Pain Relevance 0
Occasionally, high titers of c-ANCA can be detected in AIH-1 (Dalekos GN, 2002, unpublished observations).
Gene_expression (detected) of AIH-1 associated with autoimmune hepatitis
4) Confidence 0.05 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.61 Pain Relevance 0.12

General Comments

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