INT144908

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.81
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 1
plasma 1
muscle 1
arms 1
legs 1
SEA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
sodium channel 4 100.00 Very High Very High Very High
tetrodotoxin 1 100.00 Very High Very High Very High
TRP channel 10 97.08 Very High Very High Very High
dorsal root ganglion 3 96.60 Very High Very High Very High
adenocard 14 90.52 High High
Inflammation 42 70.76 Quite High
Pain 8 50.76 Quite High
agonist 13 13.16 Low Low
Mechanotransduction 5 10.48 Low Low
Disease Link Frequency Relevance Heat
Poisoning 2 99.60 Very High Very High Very High
Influenza In Birds 7 99.02 Very High Very High Very High
Helminth Infection 48 98.20 Very High Very High Very High
Ganglion Cysts 3 96.60 Very High Very High Very High
Skin Cancer 3 94.56 High High
Toothache 6 90.80 High High
Disease 86 90.20 High High
Death 14 83.04 Quite High
Paralysis 2 81.64 Quite High
Reprotox - General 3 3 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While cases of avian flu in animals or humans have so far not yet been officially detected in Turkmenistan, carcasses of migratory birds suspected of carrying the Avian flu virus were discovered on Turkmenistan's Caspian Sea coast early in 2006 [33].
Gene_expression (coast) of Sea associated with influenza in birds
1) Confidence 0.52 Published 2007 Journal BMC Med Section Body Doc Link PMC1948003 Disease Relevance 0.84 Pain Relevance 0
Also, the behavioral effects of crotamine intoxication were compared with those of a muscle-selective sodium channel antagonist mu-CgTx-GIIIA, and other sodium-acting toxins such as tetrodotoxin alpha- and beta-pompilidotoxins, sea anemone toxin BcIII, spider toxin Tx2-6.
Gene_expression (those) of sea in muscle associated with tetrodotoxin, antagonist, sodium channel and poisoning
2) Confidence 0.29 Published 2007 Journal Toxicon Section Abstract Doc Link 17588630 Disease Relevance 0.57 Pain Relevance 0.43
When evaluating the results from the Swedish Fishermen's Families Cohorts studies, it is important to keep in mind that the main exposure source for POP, namely fatty fish from the Baltic Sea, is also an exposure route for other constituents of fish.
Gene_expression (source) of Sea
3) Confidence 0.27 Published 2008 Journal Environ Health Section Body Doc Link PMC2438351 Disease Relevance 0.08 Pain Relevance 0
Pliny the Elder wrote of the Greek, Agatharchidas, that “people of the Red Sea suffered many strange and unheard attacks … worms and little snakes came out upon them, gnawed away their legs and arms and when touched, retracted … giving rise to unsupportable pains”.
Gene_expression (people) of Sea in arms associated with helminth infection
4) Confidence 0.19 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.86 Pain Relevance 0.09
This study is the first to show the developmental expression of SpREJ in sea urchin embryos.
Gene_expression (expression) of sea in embryos
5) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Expression of SpREJ genes in adult sea urchin tissues
Gene_expression (tissues) of sea
6) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
It was previously shown that SpREJ1 is localized in the plasma membrane covering the acrosome vesicle and flagella of sea urchin spermatozoa, but its expression in nongametic cells of the testis has not been studied.
Gene_expression (expression) of sea in spermatozoa
7) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
That the sea urchin has 10 SpREJ genes, while the human has five, shows either that humans lost ancestral PKD1 orthologs, or conversely, sea urchins gained new SpREJ genes.
Gene_expression (urchin) of sea
8) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Mammalian PKDREJ, like sea urchin SpREJ3, is found only in the plasma membrane covering the sperm acrosomal vesicle [21].
Gene_expression (found) of sea in plasma
9) Confidence 0.13 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.39 Pain Relevance 0.09
An SEA domain is also present in enteropeptidase, another TTSP family member, in all of the HAT/DESC (human airway trypsin-like protease/differentially expressed in squamous cell carcinoma) subfamily proteins and in the closely related matriptase and matriptase-3 [20].
Gene_expression (present) of SEA associated with skin cancer
10) Confidence 0.11 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.22 Pain Relevance 0
Pliny the Elder wrote of the Greek, Agatharchidas, that “people of the Red Sea suffered many strange and unheard attacks … worms and little snakes came out upon them, gnawed away their legs and arms and when touched, retracted … giving rise to unsupportable pains”.
Gene_expression (people) of Sea in legs associated with helminth infection
11) Confidence 0.06 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.86 Pain Relevance 0.09
Therefore, they were suggested to have important ecological functions, resembling those ascribed to similar compounds present in sea stars, sea cucumbers, and terrestrial plants [116].
Gene_expression (stars) of sea
12) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852841 Disease Relevance 0 Pain Relevance 0
Therefore, they were suggested to have important ecological functions, resembling those ascribed to similar compounds present in sea stars, sea cucumbers, and terrestrial plants [116].
Gene_expression (cucumbers) of sea
13) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852841 Disease Relevance 0 Pain Relevance 0
Even cellulose and amylose have been extracted from the macroalga ULVA, which is present along the coasts of Mediterranean Sea and in many lagoons including that of Venice [2].
Gene_expression (present) of Sea
14) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953395 Disease Relevance 0 Pain Relevance 0
The number of molecules in the ZINC leadlike set that are similar to the ligands of these targets was estimated using SEA,(54) insisting on a P value of 10?
Gene_expression (using) of SEA
15) Confidence 0.05 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2865168 Disease Relevance 0 Pain Relevance 0.09

General Comments

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