INT144918

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.39
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thy1) endoplasmic reticulum (Thy1) plasma membrane (Thy1)
enzyme binding (Thy1) cytoskeleton organization (Thy1)
Anatomy Link Frequency
optic nerve 1
RGC 1
Thy1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 24 61.08 Quite High
Endocannabinoid 4 50.00 Quite Low
Action potential 10 49.76 Quite Low
qutenza 2 10.00 Low Low
anesthesia 11 5.00 Very Low Very Low Very Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
potassium channel 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 57 98.96 Very High Very High Very High
Death 13 98.56 Very High Very High Very High
Injury 97 97.80 Very High Very High Very High
Targeted Disruption 44 93.76 High High
Stress 26 91.12 High High
Glaucoma 73 88.72 High High
Apoptosis 21 85.08 High High
Ocular Hypertension 102 83.04 Quite High
Gliosis 11 75.72 Quite High
Hypertrophy 13 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When changes in thy-1 expression were compared to the time course of RGC cell loss, it is clear that a significant loss of thy-1 mRNA and protein occurs well in advance of RGC cell loss.
Gene_expression (expression) of thy-1
1) Confidence 0.62 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.39 Pain Relevance 0
When changes in thy-1 expression were compared to the time course of RGC cell loss, it is clear that a significant loss of thy-1 mRNA and protein precedes RGC cell loss.
Gene_expression (precedes) of thy-1
2) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.17 Pain Relevance 0.03
Reduction of rat retinal ganglion cells after optic nerve crush and correlation with thy-1 mRNA and protein levels
Gene_expression (levels) of thy-1 in optic nerve associated with ganglion cysts
3) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.17 Pain Relevance 0
When changes in thy-1 expression were compared to the time course of RGC cell loss, it is clear that a significant loss of thy-1 mRNA and protein precedes RGC cell loss.
Gene_expression (expression) of thy-1
4) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.07 Pain Relevance 0.03
The sustained increase in GFAP indicates astrogliosis, while the decreased bcl-xl protein level suggests a commitment to cellular death, as clearly shown by the reduction in the RGC population and decreased thy-1 expression.
Gene_expression (expression) of thy-1 associated with death
5) Confidence 0.48 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.37 Pain Relevance 0
This is consistent with findings that the Thy-1.2 antigen is expressed in some of these cells at low level, even though Thy-1.2 has been considered to be a “specific” marker of RCGs [16], [17], [25].
Gene_expression (expressed) of Thy-1
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.22 Pain Relevance 0
Thus, the Thy-1.2 promoter is an effective regulator of a gene that is expressed exclusively in the RGCs [18], [19], [20].
Gene_expression (expressed) of Thy-1
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.17 Pain Relevance 0
Finally, to characterize the neuroprotective profile of drugs that interfere with the endocannabinoid system, cell counting in the retinal ganglion cell (RGC) layer and real-time polymerase chain reactions for Thy-1 mRNA expression were used.
Gene_expression (expression) of Thy-1 mRNA in RGC
8) Confidence 0.18 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
Changes in AQP4, caspase-3, thy-1, ubiquitination, and GFAP expression were also followed in total retinal extracts using western blotting.
Gene_expression (expression) of thy-1
9) Confidence 0.09 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.82 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox