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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerve 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 99.98 Very High Very High Very High
qutenza 17 99.64 Very High Very High Very High
Osteoarthritis 45 98.72 Very High Very High Very High
analgesia 12 98.38 Very High Very High Very High
IPN 8 96.92 Very High Very High Very High
Nerve growth factor 23 92.36 High High
bradykinin 6 88.60 High High
Inflammation 32 87.08 High High
TRP channel 3 77.32 Quite High
vanilloid receptor subtype 1 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Frailty 48 98.72 Very High Very High Very High
Neuropathic Pain 21 97.56 Very High Very High Very High
Inflammatory Pain 8 96.92 Very High Very High Very High
Shock 1 94.80 High High
INFLAMMATION 40 87.08 High High
Pain 118 70.64 Quite High
Hyperalgesia 11 58.40 Quite High
Arthritis 4 50.00 Quite Low
Injury 10 49.96 Quite Low
Nociception 9 18.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agonist-induced desensitization of the transient receptor potential vanilloid receptor-1 (TRPV1) is one of the key strategies that offer a way to alleviate neuropathic and inflammatory pain.
Positive_regulation (induced) of Negative_regulation (desensitization) of TRPV1 associated with ipn, neuropathic pain and agonist
1) Confidence 0.46 Published 2007 Journal Neuroscience Section Abstract Doc Link 17869438 Disease Relevance 0.19 Pain Relevance 0.22
The PLC inhibitor U73122 and dialysis of PtdIns(4,5)P2 or PtdIns(4)P through the patch pipette inhibited desensitization of TRPV1, indicating that Ca2+-induced activation of PLC contributes to desensitization of TRPV1 by depletion of PtdIns(4,5)P2 and PtdIns(4)P.
Positive_regulation (contributes) of Negative_regulation (desensitization) of TRPV1
2) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17596456 Disease Relevance 0 Pain Relevance 0.44
Analgesia approaches in OA have used capsaicin preparations or capsaicin-like agonists to induce TRPV1 desensitization or reversible sensory nerve terminal degeneration caused by prolonged cation influx into the nerve, osmotic damage and metabolic collapse [97].
Positive_regulation (induce) of Negative_regulation (desensitization) of TRPV1 in nerve associated with qutenza, shock, agonist, osteoarthritis and analgesia
3) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.65 Pain Relevance 1.23

General Comments

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