INT144945

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 26.23
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
monocytes 2
endothelial cells 2
plasma 1
macrophages 1
liver 1
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 527 100.00 Very High Very High Very High
anesthesia 29 99.70 Very High Very High Very High
isoflurane 15 99.48 Very High Very High Very High
cytokine 206 99.16 Very High Very High Very High
ischemia 154 96.76 Very High Very High Very High
adenocard 2 96.04 Very High Very High Very High
Central nervous system 13 95.20 Very High Very High Very High
Inflammatory response 126 94.32 High High
metalloproteinase 68 92.92 High High
Inflammatory mediators 46 87.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 676 100.00 Very High Very High Very High
Adhesions 356 100.00 Very High Very High Very High
Hypothermia 115 99.98 Very High Very High Very High
Rheumatoid Arthritis 9 99.98 Very High Very High Very High
Uveitis 129 99.90 Very High Very High Very High
Diabetes Mellitus 67 98.84 Very High Very High Very High
Disease 84 98.60 Very High Very High Very High
Bacterial Respiratory Disease 4 97.20 Very High Very High Very High
Injury 456 96.88 Very High Very High Very High
Cv Unclassified Under Development 125 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed below, there are a number of possible explanations as to why P-selectin and ICAM-1 deficiency did not appear to be critical for neutrophil infiltration and hepatocellular injury following liver I/R.
Negative_regulation (deficiency) of ICAM-1 in liver associated with injury
1) Confidence 0.50 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.97 Pain Relevance 0.08
In separate experiments, we administered AdTNF-alpha or AdIL-1beta to mice deficient in ICAM-1.
Negative_regulation (deficient) of ICAM-1
2) Confidence 0.50 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.63 Pain Relevance 0.23
In the present study we found no correlation between MCP-1 and radical levels and a negative correlation between ICAM-1 and these levels.
Negative_regulation (correlation) of ICAM-1
3) Confidence 0.40 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.99 Pain Relevance 0.52
Verification of ICAM-1 and P-selectin deficiency in P/I null mice
Negative_regulation (deficiency) of ICAM
4) Confidence 0.38 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.09 Pain Relevance 0
Further, the lack of ICAM-1, per se, is not a critical factor that results in dysfunctional ?
Negative_regulation (lack) of ICAM
5) Confidence 0.38 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.10 Pain Relevance 0.08
Verification of ICAM-1 deficiency in P/I null mice
Negative_regulation (deficiency) of ICAM-1
6) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.33 Pain Relevance 0
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Negative_regulation (reduction) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
7) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.38 Pain Relevance 1.09
Some of the Cox-2 dependent genes from this study have been previously identified as being influenced by Cox-2 or Cox-2 inhibition (Gast, Icam1, Odc), but the remainder are novel and point to new links between Cox-2 and inflammatory processes, epithelial repair and integrity.
Negative_regulation (inhibition) of Icam1 associated with inflammation
8) Confidence 0.32 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.61 Pain Relevance 0.18
In fact, Tull et al. showed that EPA had no ability to decrease adhesion molecules such as E-selectin and ICAM-1, representatives of endothelial surface adhesion molecules, in cultured endothelial cells stimulated with TNF-?
Negative_regulation (decrease) of ICAM-1 in endothelial cells associated with adhesions
9) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.91 Pain Relevance 0.04
Interestingly, in this study the level of the ICAM-1 protein, an endothelial adhesion molecule regulating leukocyte recruitment, was not decreased by EPA in the inflamed ocular tissues.
Neg (not) Negative_regulation (decreased) of ICAM-1 in leukocyte associated with adhesions
10) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.13 Pain Relevance 0.39
To investigate whether supplemental EPA may suppress inflammatory molecules in the uveal tissue during EIU, we measured MCP-1, IL-6, and ICAM-1 in the RPE-choroid complex.
Negative_regulation (measured) of ICAM-1 in choroid associated with inflammation and uveitis
11) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.97 Pain Relevance 0.15
Both subjective (symptom scores) and objective (impression cytology) parameters established the antiallergic activity of azelastine in the eye, and confirmed its inhibitory effect on infiltration of inflammation and downregulation of ICAM-1, which was first observed in the nasal mucosa.14
Negative_regulation (downregulation) of ICAM-1 in nasal mucosa associated with inflammation
12) Confidence 0.27 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938280 Disease Relevance 0.67 Pain Relevance 0.09
Interaction of monocytes with endothelial cells is mediated by adhesion molecules located on the surface of these cells, which include VCAM-1, ICAM-1, and E-selectin.
Negative_regulation (include) of ICAM-1 in endothelial cells associated with adhesions
13) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.09 Pain Relevance 0.18
Pretreatment with topical polyethylene glycol hydrogel delivery of ICAM-1 antisense oligonucleotides demonstrated decreased ICAM-1 mRNA expression, reduced ICAM-1 protein staining, and decreased cellular damage in a murine partial nephrectomy/ischemia model [74].
Negative_regulation (reduced) of ICAM-1 associated with ischemia
14) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.56 Pain Relevance 0.29
In zymosan-treated mice, an increase of immunohistochemical staining for ICAM-1 and P-selectin was demonstrated in the pancreas (Figure 8A, 9A respectively) lung (Figure 8B, 9B respectively) and gut(Figure 8C, 9C respectively), (see arrows) while the immunostainings for ICAM-1 and P-selectin were markedly reduced in pancreas (Figure 8D, 9D respectively) lung (Figure 8E, 9E respectively) and gut(Figure 8F, 9F respectively) tissues obtained from mice, that were treated with GW0742.
Negative_regulation (reduced) of ICAM-1 in pancreas
15) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.33 Pain Relevance 0.04
Azelastine minimizes ocular surface damage through inhibition of immune cells that characterize the late-phase immune reaction, including downregulation of intercellular adhesion molecule (ICAM)-1 on conjunctival epithelial cells.14
Negative_regulation (downregulation) of intercellular adhesion molecule in epithelial cells associated with adhesions
16) Confidence 0.20 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938280 Disease Relevance 1.13 Pain Relevance 0.21
In type 2 diabetic patients, ARBs diminished VCAM-1, whereas ACE inhibitors reduced ICAM-1 (Guba et al 2000).
Negative_regulation (reduced) of ICAM-1 associated with diabetes mellitus
17) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.22 Pain Relevance 0.29
Furthermore, 2 hours of mild post-ischemic hypothermia reduces ICAM-1 levels in brain and plasma for up to 7 days after 2 hours of MCAo [162,166,175].
Negative_regulation (reduces) of ICAM-1 in plasma associated with hypothermia
18) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.15 Pain Relevance 0.08
Functional redundancy of adhesion molecules and the cytokine production may be sufficient to compensate for the absence of P-selectin and ICAM-1 in mediating neutrophil infiltration into peritoneal cavity in response to CLP in P/I null mice.
Negative_regulation (absence) of ICAM in peritoneal cavity associated with adhesions and cytokine
19) Confidence 0.17 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.06 Pain Relevance 0.11
Gene-targeted double mutant mice deficient in P-selectin and ICAM-1 (P/I double mutant), C57BL/6-Icam1tm1BaySelptm1Bay, were used in this study.
Negative_regulation (deficient) of ICAM-1
20) Confidence 0.16 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.51 Pain Relevance 0.03

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