INT144946

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 21.84
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 4
cleavage 3
neutrophil 3
macrophages 1
pancreas 1
Icam1 (Mus musculus)
Icam1 - K469E (1)
Pain Link Frequency Relevance Heat
metalloproteinase 37 99.92 Very High Very High Very High
Inflammation 245 99.54 Very High Very High Very High
Inflammatory response 54 97.68 Very High Very High Very High
anesthesia 19 96.18 Very High Very High Very High
isoflurane 14 95.96 Very High Very High Very High
Angina 104 90.48 High High
allodynia 4 86.32 High High
ischemia 20 79.44 Quite High
medulla 10 79.04 Quite High
Spinal cord 83 76.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 182 100.00 Very High Very High Very High
Alzheimer's Dementia 1 100.00 Very High Very High Very High
Enteropathy 1 100.00 Very High Very High Very High
INFLAMMATION 309 99.54 Very High Very High Very High
Coronary Heart Disease 280 99.48 Very High Very High Very High
Rheumatoid Arthritis 4 99.36 Very High Very High Very High
Injury 129 98.64 Very High Very High Very High
Urological Neuroanatomy 86 98.56 Very High Very High Very High
Atherosclerosis 84 97.62 Very High Very High Very High
Bacterial Respiratory Disease 5 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main mechanism responsible for release of sICAM-1 is believed to be proteolytic cleavage of ICAM-1 from cell membranes.3 The ICAM-1 gene is located on chromosome 19 p13.2-p13.3.
Localization (located) of ICAM-1 gene in cleavage
1) Confidence 0.75 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.87 Pain Relevance 0.24
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Localization (form) of ICAM-1 in endothelial cells associated with atherosclerosis and adhesions
2) Confidence 0.75 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.82 Pain Relevance 0.20
The main mechanism responsible for release of sICAM-1 is believed to be proteolytic cleavage of ICAM-1 from cell membranes.3 The ICAM-1 gene is located on chromosome 19 p13.2-p13.3.
Localization (cleavage) of ICAM-1 in cleavage
3) Confidence 0.75 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.92 Pain Relevance 0.19
Immunohistochemical localization of nitrotyrosine, iNOS, P-selectin, ICAM and IL-1
Localization (localization) of ICAM
4) Confidence 0.73 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.15 Pain Relevance 0
Measurement of MCP-1, ICAM-1, MMP-9 and oxLDL
Localization (Measurement) of ICAM-1 associated with metalloproteinase
5) Confidence 0.70 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.09 Pain Relevance 0.09
The main mechanism responsible for release of sICAM-1 is believed to be proteolytic cleavage of ICAM-1 from cell membranes.3 The ICAM-1 gene is located on chromosome 19 p13.2-p13.3.
Localization (release) of sICAM-1 in cleavage
6) Confidence 0.70 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.84 Pain Relevance 0.19
P-selectin and ICAM-1 were immunolocalized to endothelial cells, and were double labelled with von Willebrand factor.
Localization (immunolocalized) of ICAM-1 in endothelial cells
7) Confidence 0.69 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.55 Pain Relevance 0.52
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Localization (verified) of ICAM-1
8) Confidence 0.69 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.56 Pain Relevance 0.51
Serum sICAM-1
Localization (Serum) of sICAM-1
9) Confidence 0.66 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.29 Pain Relevance 0.29
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Localization (form) of Soluble ICAM-1 in endothelial cells associated with atherosclerosis and adhesions
10) Confidence 0.66 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.85 Pain Relevance 0.20
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Localization (form) of sICAM-1 in endothelial cells associated with atherosclerosis and adhesions
11) Confidence 0.66 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.83 Pain Relevance 0.20
Molecular analysis of K469E polymorphism of ICAM-1 gene
Localization (polymorphism) of ICAM-1 gene (K469E)
12) Confidence 0.66 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 0.36 Pain Relevance 0.04
Determination of neutrophil infiltration and ICAM-1 expression by Immunohistochemistry
Localization (Determination) of ICAM in neutrophil
13) Confidence 0.66 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.58 Pain Relevance 0
Determination of neutrophil infiltration and ICAM-1 expression by Immunohistochemistry
Localization (infiltration) of ICAM in neutrophil
14) Confidence 0.66 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.57 Pain Relevance 0
In zymosan-treated mice, an increase of immunohistochemical staining for ICAM-1 and P-selectin was demonstrated in the pancreas (Figure 8A, 9A respectively) lung (Figure 8B, 9B respectively) and gut(Figure 8C, 9C respectively), (see arrows) while the immunostainings for ICAM-1 and P-selectin were markedly reduced in pancreas (Figure 8D, 9D respectively) lung (Figure 8E, 9E respectively) and gut(Figure 8F, 9F respectively) tissues obtained from mice, that were treated with GW0742.
Localization (increase) of ICAM-1 in pancreas
15) Confidence 0.35 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.26 Pain Relevance 0.08
Both subjective (symptom scores) and objective (impression cytology) parameters established the antiallergic activity of azelastine in the eye, and confirmed its inhibitory effect on infiltration of inflammation and downregulation of ICAM-1, which was first observed in the nasal mucosa.14
Localization (observed) of ICAM-1 in nasal mucosa associated with inflammation
16) Confidence 0.34 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938280 Disease Relevance 0.73 Pain Relevance 0.09
Immunohistochemical localization of nitrotyrosine, PARP, ICAM-1, P-Selectin, Bax, Bcl-2, TNF-?
Localization (localization) of ICAM-1
17) Confidence 0.33 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0 Pain Relevance 0.03
In addition, elevation of quantitative markers for enteropathy such as serum KC, serum amyloid A (SAA), and ICAM-1 (Fig. 1 D and not depicted) (19, 20) suggested that some inflammatory responses would be induced in the colon.
Spec (suggested) Localization (elevation) of ICAM-1 in colon associated with inflammatory response, alzheimer's dementia and enteropathy
18) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.89 Pain Relevance 0.09
Immunohistochemical localization of P-selectin, Intercellular Cell Adhesion Molecule (ICAM)-1, IL-1 ?
Localization (localization) of ICAM associated with adhesions
19) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 0.66 Pain Relevance 0.07
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Localization (translocation) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
20) Confidence 0.25 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.32 Pain Relevance 1.07

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