INT144959

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna3) plasma membrane (Chrna3)
Anatomy Link Frequency
mossy fibers 1
Chrna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 18 100.00 Very High Very High Very High
Hippocampus 1 75.00 Quite High
lidocaine 4 59.68 Quite High
Serotonin 1 54.00 Quite High
sodium channel 2 49.92 Quite Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 18 50.00 Quite Low
Heart Rate Under Development 19 48.96 Quite Low
Coronary Heart Disease 3 36.88 Quite Low
Sprains And Strains 18 22.28 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Syncope 1 5.00 Very Low Very Low Very Low
Communicable Diseases 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene ontology analysis then revealed that most of the 65 known genes were related to "metal ion binding", "protein binding", or "synaptic transmission" functions, and some of these presented "receptor/transporter/channel activity", some of which have an ion channel activity (Chrna5, Chrna3, Chrnb4, Htr3a, Htr3b, Fxyd2, and Hcn4).
Chrna3 Binding (binding) of
1) Confidence 0.29 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1865373 Disease Relevance 0 Pain Relevance 0.03
Present experiments investigate interactions between a rat model of the novelty-seeking phenotype and psychomotor sensitization to nicotine (NIC) in adolescence, and the potential role of hippocampal mossy fibers in mediating the behaviorally-sensitizing effects of NIC.
nicotine Binding (interactions) of in mossy fibers associated with nicotine
2) Confidence 0.01 Published 2007 Journal Hippocampus Section Abstract Doc Link 17598146 Disease Relevance 0 Pain Relevance 0.34

General Comments

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