INT144966

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1, EGR1) DNA binding (MAPK1, EGR1) cytoplasm (MAPK1, EGR1)
nucleus (MAPK1, EGR1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
MAPK1 (Homo sapiens)
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 73.68 Quite High
Inflammation 1 63.76 Quite High
Pain 1 63.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 95.68 Very High Very High Very High
Death 2 94.48 High High
Cancer 2 83.56 Quite High
Injury 2 76.04 Quite High
Ulcers 1 71.48 Quite High
INFLAMMATION 2 63.76 Quite High
Pain 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, sulindac sulfide stimulated the nuclear translocation of the transcription factor EGR-1, which was also mediated by ERK1/2 signaling pathway.
ERK1/2 Positive_regulation (mediated) of Localization (translocation) of EGR-1
1) Confidence 0.08 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.83 Pain Relevance 0.35

General Comments

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