INT144969

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.12
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
epithelial cells 1
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 98.04 Very High Very High Very High
Inflammation 18 86.16 High High
Bioavailability 2 85.80 High High
Pain 3 85.48 High High
imagery 4 24.76 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 14 100.00 Very High Very High Very High
Renal Cell Carcinoma 58 99.68 Very High Very High Very High
Injury 3 99.22 Very High Very High Very High
Cancer 171 98.04 Very High Very High Very High
Ulcers 1 93.88 High High
Ovarian Cancer 59 93.28 High High
Aggression 2 92.40 High High
Stress 13 88.96 High High
Diabetes Mellitus 25 87.56 High High
INFLAMMATION 24 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mTOR kinase also controls angiogenic pathways via hypoxia-inducible factor-1?
hypoxia-inducible factor Binding (pathways) of associated with hypoxia
1) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.89 Pain Relevance 0
dimerizes with HIF-?
HIF Binding (dimerizes) of
2) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.85 Pain Relevance 0
Hypoxic conditions also increase the activity of hypoxia-inducible factor (HIF-1?)
hypoxia-inducible factor Binding (activity) of associated with hypoxia
3) Confidence 0.03 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.76 Pain Relevance 0.04
In the present study, NSAID sulindac sulfide was investigated for the cytotoxic injury in the intestinal epithelial cells in association with an immediate inducible factor, early growth response gene 1 (EGR-1).
immediate inducible factor Binding (association) of in epithelial cells associated with injury and cinod
4) Confidence 0.03 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.63 Pain Relevance 0.40

General Comments

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