INT14497

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 82
Total Number 84
Disease Relevance 17.67
Pain Relevance 32.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRP) extracellular space (GRP) extracellular region (GRP)
Anatomy Link Frequency
neurons 10
nerve 8
pyramidal neurons 3
muscle 3
pancreatic islets 2
GRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 221 100.00 Very High Very High Very High
gABA 179 100.00 Very High Very High Very High
Enkephalin 120 100.00 Very High Very High Very High
Dorsal column 90 100.00 Very High Very High Very High
substance P 79 100.00 Very High Very High Very High
Somatostatin 72 100.00 Very High Very High Very High
Cholecystokinin 58 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
agonist 59 99.98 Very High Very High Very High
antagonist 223 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 44 100.00 Very High Very High Very High
Pancreatic Cancer 20 100.00 Very High Very High Very High
Metastasis 6 99.74 Very High Very High Very High
Headache 5 99.72 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 15 99.56 Very High Very High Very High
Pancreatitis 27 99.36 Very High Very High Very High
Pruritus 199 99.04 Very High Very High Very High
Neuroendocrine Cancer 8 98.96 Very High Very High Very High
Injury 402 98.16 Very High Very High Very High
Increased Venous Pressure Under Development 9 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastrin-releasing peptide (GRP, 10(-9)-10(-7) mol L-1) produced two types of response in the different muscle layers.
Gene_expression (produced) of Gastrin-releasing peptide in muscle
1) Confidence 0.78 Published 1997 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 9430795 Disease Relevance 0 Pain Relevance 0.07
Gastrin-releasing peptide (GRP, 10(-9)-10(-7) mol L-1) produced two types of response in the different muscle layers.
Gene_expression (produced) of GRP in muscle
2) Confidence 0.78 Published 1997 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 9430795 Disease Relevance 0 Pain Relevance 0.07
Bombesin was present in 18 of the 27 cases, serotonin in 15, leu-enkephalin in 8, somatostatin in 8, gastrin in 3, substance P in 1, vasoactive intestinal peptide (VIP) in 1, and ACTH in 1.
Gene_expression (present) of Bombesin associated with somatostatin, enkephalin, serotonin and substance p
3) Confidence 0.75 Published 1985 Journal Ultrastruct Pathol Section Abstract Doc Link 3901454 Disease Relevance 0.56 Pain Relevance 0.29
The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line.
Gene_expression (co-expressed) of gastrin-releasing peptide associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
4) Confidence 0.75 Published 1990 Journal FEBS Lett. Section Title Doc Link 2384178 Disease Relevance 0.19 Pain Relevance 0.82
Particularly, GRP receptor was co-localized with GAD67, a marker for GABA in some neurons, suggesting GRP receptor is expressed in a subpopulation of GABAergic interneurons.
Gene_expression (expressed) of GRP in neurons associated with gaba and gabaergic
5) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.71
We found that GRP receptor was highly expressed in these areas.
Gene_expression (expressed) of GRP
6) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.65
Interestingly, in the present study, although ACC pyramidal neurons are shown to express GRP receptors, we found little direct effect of GRP on these cell bodies nor on the frequency and amplitude of sEPSC.
Gene_expression (express) of GRP in pyramidal neurons associated with pyramidal cell and anterior cingulate cortex
7) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0.13 Pain Relevance 0.90
Since GRP receptor is expressed in many neurons in the ACC, we wanted to know whether it may function differently in different types of neurons, i.e pyramidal neurons and inhibitory interneurons.
Gene_expression (expressed) of GRP in pyramidal neurons associated with pyramidal cell and anterior cingulate cortex
8) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.77
Serosal GRP produced a biphasic response consisting of a transient increase in short-circuit current (ISC) followed by a long-lasting decrease.
Gene_expression (produced) of GRP
9) Confidence 0.72 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638666 Disease Relevance 0 Pain Relevance 0.12
No measurable bombesin receptors were found in the tumor tissue of ductal pancreatic carcinomas, however, GRP receptors were detected in a subset of peritumoral small veins in 19 of 29 samples.
Gene_expression (detected) of GRP in veins associated with cancer and pancreatic cancer
10) Confidence 0.72 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 11140694 Disease Relevance 0.73 Pain Relevance 0.34
Neurons containing gastrin releasing peptide-like immunoreactivity in the human pancreas.
Gene_expression (containing) of gastrin releasing peptide in pancreas associated with neuropeptide
11) Confidence 0.67 Published 1993 Journal Pancreas Section Title Doc Link 8361958 Disease Relevance 0.06 Pain Relevance 0.11
With the exception of bombesin, all the other neuropeptides appear to produce their effects through a vagally mediated mechanism.
Gene_expression (produce) of bombesin associated with neuropeptide
12) Confidence 0.65 Published 1982 Journal Life Sci. Section Abstract Doc Link 6127583 Disease Relevance 0.17 Pain Relevance 0.39
[Met5]enkephalin, [Met5]enkephalin-Arg6-Phe7 and bombesin-gastrin-releasing peptide-like immunoreactivities were localized in varicose nerve fibers, which often formed basket-like networks around principal ganglion cells.
Gene_expression (releasing) of gastrin-releasing peptide in ganglion cells associated with ganglion cysts and enkephalin
13) Confidence 0.65 Published 1984 Journal Neuroscience Section Abstract Doc Link 6206441 Disease Relevance 0.10 Pain Relevance 0.46
These data demonstrate the presence of bombesin receptors in three distinct tissue compartments of the pancreas, namely GRP receptors in the exocrine parenchyma in chronic pancreatitis and in peritumoral vessels around ductal pancreatic carcinomas, and BB3 receptors in residual pancreatic islets.
Gene_expression (presence) of bombesin in pancreatic islets associated with pancreatic cancer and chronic pancreatitis
14) Confidence 0.65 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 11140694 Disease Relevance 0.72 Pain Relevance 0.39
No measurable bombesin receptors were found in the tumor tissue of ductal pancreatic carcinomas, however, GRP receptors were detected in a subset of peritumoral small veins in 19 of 29 samples.
Gene_expression (detected) of bombesin in veins associated with cancer and pancreatic cancer
15) Confidence 0.65 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 11140694 Disease Relevance 0.75 Pain Relevance 0.35
Six of seven secondary tumors stained for bombesin, leucine enkephalin, methionine enkephalin, or beta-endorphin, none of which was detected in the primary cutaneous neuroendocrine carcinomas.
Gene_expression (detected) of bombesin associated with neuroendocrine cancer, enkephalin and metastasis
16) Confidence 0.65 Published 1985 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 3161911 Disease Relevance 1.14 Pain Relevance 0.20
CGRP levels increase in the cranial circulation during migraine attacks, and GRP injection in migraineurs results in migraine-like attacks.
Gene_expression (injection) of GRP in cranial associated with calcitonin gene related peptide and migraine
17) Confidence 0.65 Published 2009 Journal Curr Opin Pharmacol Section Abstract Doc Link 19157980 Disease Relevance 0.96 Pain Relevance 1.12
The cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropeptides cholecystokinin (CCK), neuropeptide Y, gastrin-releasing peptide (GRP) and enkephalin.
Gene_expression (expressed) of GRP associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
18) Confidence 0.65 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2384178 Disease Relevance 0.17 Pain Relevance 0.65
The cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropeptides cholecystokinin (CCK), neuropeptide Y, gastrin-releasing peptide (GRP) and enkephalin.
Gene_expression (expressed) of gastrin-releasing peptide associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
19) Confidence 0.65 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2384178 Disease Relevance 0.17 Pain Relevance 0.65
Similar results on GRP modulation of GABAergic transmission were observed in the insular cortex and amygdala, suggesting a general possible effect of GRP on cortical inhibitory transmission.
Gene_expression (modulation) of GRP in amygdala associated with gabaergic and amygdala
20) Confidence 0.64 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945970 Disease Relevance 0.13 Pain Relevance 0.42

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