INT144973

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 43
Disease Relevance 4.32
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
MSCs 4
bone marrow 2
heart 2
myocardium 1
embryos 1
Shh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 9 98.48 Very High Very High Very High
cytokine 108 97.96 Very High Very High Very High
Inflammation 41 97.60 Very High Very High Very High
IPN 6 97.32 Very High Very High Very High
fibrosis 35 94.64 High High
metalloproteinase 35 92.64 High High
ischemia 35 87.96 High High
Neuronal nitric oxide synthase 35 87.60 High High
anesthesia 38 86.96 High High
Central nervous system 35 61.68 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 9 98.48 Very High Very High Very High
Osteoporosis 8 98.24 Very High Very High Very High
INFLAMMATION 76 97.60 Very High Very High Very High
Apoptosis 65 96.18 Very High Very High Very High
Diabetes Mellitus 150 95.60 Very High Very High Very High
Fibrosis 35 94.64 High High
Injury 70 94.44 High High
Gestational Diabetes 27 92.20 High High
Cancer 41 89.76 High High
Cv Unclassified Under Development 35 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Compared with the control group (A), the serum bilirubin and amylase in the model group increased significantly after 7 days of treatment, and fibrotic proliferation of pancreatic tissues were found after 35 days; the expression of PTCH-1, SMO, and SHH in the pancreatic tissue increased significantly in the model group.
Gene_expression (expression) of SHH
1) Confidence 0.77 Published 2010 Journal Saudi Med J Section Body Doc Link 20062892 Disease Relevance 0.06 Pain Relevance 0
Expression of patched-1 (PTCH-1), smoothened (SMO), and SHH were detected by immunohistochemistry.
Gene_expression (detected) of SHH
2) Confidence 0.77 Published 2010 Journal Saudi Med J Section Body Doc Link 20062892 Disease Relevance 0.07 Pain Relevance 0
These molecular changes were mediated by iNOS/netrin/PKC signaling pathway downstream of Shh gene overexpression which combined with stem cell transplantation could be a promising strategy for the treatment of an infarcted heart.


Gene_expression (overexpression) of Shh gene in stem cell
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.05
An outside intervention to overexpress Shh in the heart activated its downstream signaling cascade and strongly induced Patched1 (Ptc1) expression in the cardiomyocytes which indicated an active participation of Shh in the myocardial repair process.
Gene_expression (overexpress) of Shh in heart
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.26 Pain Relevance 0.04
Immunofluorescence, RT-PCR and Western blotting showed higher expression of Shh in ShhMSCs which also led to increased expression of angiogenic and pro-survival growth factors in ShhMSCs.
Gene_expression (expression) of Shh
5) Confidence 0.74 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797399 Disease Relevance 0.07 Pain Relevance 0
During Western blot studies, subsequent Shh transfection of the respective siRNA transfected cells showed that PI3K/Akt abrogation failed to block Shh induced iNOS expression (Figure 3D; lane-3).
Gene_expression (expression) of Shh
6) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
Our results were in harmony with these data and further showed uniquely that Shh gene overexpression up-regulated iNOS, netrin-1 and HGF in addition to the already reported cytokines.
Gene_expression (overexpression) of Shh gene in HGF associated with cytokine
7) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.15 Pain Relevance 0.20
Measurement of NO activity by using a colorimetric NO assay kit showed that Shh overexpression was associated with a concomitant increase in NO production in ShhMSCs (Figure 3C).
Gene_expression (overexpression) of Shh
8) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
The anticipated objective of our multipronged strategy was to achieve intracrine, autocrine, and paracrine effects of Shh protein which was secreted from MSCs overexpressing Shh (ShhMSCs) and regenerated the damaged tissue, induced revascularization and concomitantly prevented remodeling of the heart by preserving the existing myocardium.
Gene_expression (overexpressing) of ShhMSCs in MSCs
9) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0
Treatment of the cells with Shh or instrinsic Shh gene overexpression in response to various factors involve signaling pathways including PI3K/Akt, Ras/ERK and PKC.
Gene_expression (overexpression) of Shh gene
10) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.08 Pain Relevance 0
A few previous studies have reported increased MMP-9 the Shh-expressing cells, which was attenuated by the inhibition of EGF receptor activation or blocking the EGF receptor and ligand interaction [22].
Gene_expression (expressing) of Shh
11) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.10
In the present study we took advantage of the anti-apoptotic and pro-angiogenic role of Shh signaling and combined Shh transgene delivery to the infarcted heart by transplantation of mesenchymal stem cells (MSCs) which were non-virally transfected to overexpress Shh.
Gene_expression (overexpress) of Shh in heart associated with apoptosis
12) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.10 Pain Relevance 0
In addition to upregulation of Ptc1, overexpression of Shh in MSCs stimulated the expression of secretable angiogenic growth factors including Ang-1 and VEGF.
Gene_expression (overexpression) of Shh
13) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.06
Another interesting finding in the present study was the presence of PKM fragment of PKC in ShhMSCs at 72-h after transfection with Shh plasmid.
Gene_expression (transfection) of Shh plasmid
14) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.08 Pain Relevance 0.03
We also found that Shh overexpression also induced panPKC fragment PKM (45 kd; a proteolytic subunit of PKC) in ShhMSCs which was completely abolished by pretreatment of the cells with 2.5 µM chel or 1 µM cyclopamine (Figure 3E).
Gene_expression (overexpression) of Shh
15) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
Enhanced angiogenesis may be attributed to the multiple effects of localized Shh transgene expression.
Gene_expression (expression) of Shh transgene
16) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0.13
The anticipated objective of our multipronged strategy was to achieve intracrine, autocrine, and paracrine effects of Shh protein which was secreted from MSCs overexpressing Shh (ShhMSCs) and regenerated the damaged tissue, induced revascularization and concomitantly prevented remodeling of the heart by preserving the existing myocardium.
Gene_expression (overexpressing) of Shh in MSCs
17) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0
However, since isolated neural stem cells exposed to glucose in vitro show increased gene expression of both Shh and Bmp-4 (50), the exact relationship(s) between gene expression changes in the surrounding tissues and the neural crest cells themselves caused by exposure to a diabetic environment will have be subject to further studies.
Gene_expression (expression) of Shh in neural associated with diabetes mellitus
18) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.47 Pain Relevance 0
Despite the absence of a significant difference in Shh mRNA levels between the MDn and MDm embryos, the decreased Shh expression in the MD offspring is of particular interest in relation to the findings of embryonic craniofacial (56) and aortic (57) anomalies resulting from direct inhibition of Shh, as well as the findings of an early role for Shh in securing the neural crest cell survival in the early development of the lower jaw (58).
Gene_expression (expression) of Shh in lower jaw
19) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.54 Pain Relevance 0.03
A recombinant cysteine-modified N-terminal Shh (mShh) was synthesized, purified, and immobilized onto interpenetrating polymer network (IPN) surfaces also grafted with a bone sialoprotein-derived peptide containing the Arg-Gly-Asp (RGD) sequence (bsp-RGD (15)), at calculated densities of 2.42 and 10 pmol/cm2, respectively.
Gene_expression (synthesized) of N-terminal Shh associated with ipn
20) Confidence 0.68 Published 2007 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 17600327 Disease Relevance 0.19 Pain Relevance 0.10

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