INT145

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Context Info
Confidence 0.39
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.68
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Plasma 1
skin 1
ganglia 1
gastric corpus 1
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 18 100.00 Very High Very High Very High
anesthesia 12 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
aspirin 8 99.48 Very High Very High Very High
opiate 1 99.12 Very High Very High Very High
Clonidine 16 99.04 Very High Very High Very High
qutenza 8 96.16 Very High Very High Very High
tetrodotoxin 1 95.36 Very High Very High Very High
agonist 10 94.42 High High
Opioid 1 92.80 High High
Disease Link Frequency Relevance Heat
Vomiting 25 99.80 Very High Very High Very High
Post-operative Nausea 1 98.86 Very High Very High Very High
Systemic Mastocytosis 6 98.08 Very High Very High Very High
Hyperplasia 1 97.08 Very High Very High Very High
Hypotension 6 96.84 Very High Very High Very High
Erythema 6 94.80 High High
Pressure Volume 2 Under Development 6 93.56 High High
Hypertension 1 91.36 High High
Disease 16 90.32 High High
Heart Rate Under Development 8 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that canine gastric corpus muscularis mucosae possesses both contractile H1 and relaxant H2 receptors.
Negative_regulation (possesses) of H1 in gastric corpus
1) Confidence 0.39 Published 1993 Journal Life Sci. Section Abstract Doc Link 8429755 Disease Relevance 0 Pain Relevance 0.38
Blockade of H1 and H2 receptors, as well as autonomic ganglia, resulted in a comparable attentuation of the histamine circulatory response.
Negative_regulation (Blockade) of H1 in ganglia
2) Confidence 0.32 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 13663 Disease Relevance 0.35 Pain Relevance 0.17
H1 and H2 blockade: a prophylactic principle in anesthesia and surgery against histamine-release responses of any degree of severity: Part 1.
Negative_regulation (blockade) of H1 associated with anesthesia
3) Confidence 0.13 Published 1985 Journal N Engl Reg Allergy Proc Section Title Doc Link 2442588 Disease Relevance 0.45 Pain Relevance 0.24
On the other hand, it has been suggested that the amino acid residues not only at position 193 but also at position 190 of H1 HA play a key role in interaction with the glycan in the extension region [27],[29],[31],[32].
Negative_regulation (position) of H1
4) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.07 Pain Relevance 0
Based upon the experience of others with the management of patients with systemic mastocytosis who showed exceptional reaction to cyclooxygenase inhibition, it was decided to treat him with H1 and H2 blockade followed by aspirin, another cyclooxygenase inhibitor.
Negative_regulation (blockade) of H1 associated with aspirin and systemic mastocytosis
5) Confidence 0.08 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 2880686 Disease Relevance 0.83 Pain Relevance 0.25
Cyclooxygenase inhibition, combined with H1 and H2 blockade, is an effective treatment for this condition, but for these patients initiation of aspirin therapy should be carried out with extreme care.
Negative_regulation (blockade) of H1 associated with aspirin
6) Confidence 0.08 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 2880686 Disease Relevance 0.77 Pain Relevance 0.30
Contemporary studies on Keratinocytes have shown that blocking such H1 and H2 receptors accelerates skin barrier repair and prevents epidermal hyperplasia [60].
Negative_regulation (blocking) of H1 in skin associated with hyperplasia
7) Confidence 0.08 Published 2003 Journal Filaria J Section Body Doc Link PMC153482 Disease Relevance 0.43 Pain Relevance 0.19
Centrally active adrenoceptor agonists in combination with a muscarinic antagonist or H1-receptor antagonist may offer better control of motion sickness and its associated symptoms than either antagonist alone; based on clinical studies, postoperative vomiting after opiate administration appears to be controlled by blocking dopamine D2, histamine H1- or muscarinic receptors.
Negative_regulation (blocking) of H1 associated with post-operative nausea, dopamine, antagonist, vomiting, agonist and opiate
8) Confidence 0.07 Published 1992 Journal Drugs Section Abstract Doc Link 1377113 Disease Relevance 0.88 Pain Relevance 0.74
Combined H1 and H2 receptors blockade effectively prevents the cardiovascular manifestation of histamine release.
Negative_regulation (blockade) of H1
9) Confidence 0.06 Published 2010 Journal Saudi Journal of Anaesthesia Section Body Doc Link PMC2980660 Disease Relevance 0.93 Pain Relevance 0
Blockade of H1 and H2 histamine receptors, and alpha- and beta-adrenoceptors failed to prevent the inhibitory effect of alpha-MeHA, whereas the specific H3 receptor antagonist, thioperamide, concentration dependently reversed the inhibitory effect of alpha-MeHA.
Negative_regulation (Blockade) of H1 associated with antagonist
10) Confidence 0.03 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1663460 Disease Relevance 0 Pain Relevance 0.21
Plasma extravasation and bronchoconstriction by antigen challenge with 20 micrograms/kg ovalbumin was completely blocked by combined H1 and H2 histamine receptor blockade.
Negative_regulation (blockade) of H1 in Plasma
11) Confidence 0.03 Published 1983 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6197659 Disease Relevance 0.16 Pain Relevance 1.18
The dopamine antagonist chlorpromazine, the 5-hydroxytryptamine blocking agent methysergide and the histamine H1 and H2 receptor antagonists, antazoline and cimetidine, injected intracerebroventricularly reduced or abolished the emesis produced by clonidine.
Negative_regulation (abolished) of H1 associated with dopamine, antagonist, vomiting and clonidine
12) Confidence 0.03 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9264044 Disease Relevance 0.83 Pain Relevance 1.43

General Comments

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