INT14500

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.46
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
motor neuron 4
dorsal 2
spinal cord 2
neutrophil 2
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 2 99.98 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Inflammation 3 98.24 Very High Very High Very High
Angina 2 95.40 Very High Very High Very High
cva 1 92.08 High High
Neuritis 1 91.56 High High
Pain 21 86.76 High High
pain labor 1 84.48 Quite High
palliative 1 61.12 Quite High
Dorsal horn 1 57.44 Quite High
Disease Link Frequency Relevance Heat
Pain 18 99.98 Very High Very High Very High
Motor Neuron Diseases 2 99.98 Very High Very High Very High
Malignant Neoplastic Disease 2 99.20 Very High Very High Very High
Renal Disease 10 98.52 Very High Very High Very High
Respiratory Failure 6 98.28 Very High Very High Very High
INFLAMMATION 3 98.24 Very High Very High Very High
Neuropathic Pain 8 97.84 Very High Very High Very High
Syndrome 11 96.16 Very High Very High Very High
Cv General 3 Under Development 3 95.40 Very High Very High Very High
Disease 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with our previous animal study and the idea that persistent pain induces the synthesis and release of cystatin C in dorsal spinal cord, the surplus of which overflows into the CSF.
Positive_regulation (induces) of Gene_expression (synthesis) of cystatin C in dorsal associated with pain, lasting pain and spinal cord
1) Confidence 0.67 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.61 Pain Relevance 0.67
A recent subtractive cDNA cloning study in rats demonstrated an unexpected increase in expression of the proteinase inhibitor, cystatin C in the spinal cord during acute peripheral inflammation, suggesting this protein may be involved in the pathogenesis of persistent pain.
Positive_regulation (increase) of Gene_expression (expression) of cystatin C in spinal cord associated with pain, inflammation, lasting pain and spinal cord
2) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.70 Pain Relevance 0.70
The NGAL levels were significantly higher 2 h after the PCI (serum NGAL) or 4 h after the PCI (urinary NGAL), whereas the cystatin C values were higher only 8 and 24 h after a PCI procedure in patients with CIN.
Positive_regulation (higher) of Gene_expression (values) of cystatin C associated with renal disease
3) Confidence 0.49 Published 2007 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17901710 Disease Relevance 0.55 Pain Relevance 0.07
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
Positive_regulation (Could) of Gene_expression (predict) of cystatin C in neutrophil associated with angina and renal disease
4) Confidence 0.49 Published 2007 Journal Kidney Blood Press. Res. Section Title Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.10
There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase.
Positive_regulation (increase) of Gene_expression (levels) of cystatin C
5) Confidence 0.49 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18362310 Disease Relevance 1.85 Pain Relevance 0.06
He received intravenous gamma globulin and recovered.
Positive_regulation (recovered) of Gene_expression (recovered) of gamma globulin
6) Confidence 0.44 Published 1990 Journal Am. Heart J. Section Abstract Doc Link 1696427 Disease Relevance 0.35 Pain Relevance 0.14
[An autopsy case with lower motor neuron disease showing a transient-appearance of anti-GM1 antibody and an improvement of conduction block after gamma-globulin administration].
Positive_regulation (after) of Gene_expression (administration) of gamma-globulin in motor neuron associated with motor neuron diseases
7) Confidence 0.29 Published 1999 Journal No To Shinkei Section Title Doc Link 10396755 Disease Relevance 0.88 Pain Relevance 0
[An autopsy case with lower motor neuron disease showing a transient-appearance of anti-GM1 antibody and an improvement of conduction block after gamma-globulin administration].
Positive_regulation (showing) of Gene_expression (administration) of gamma-globulin in motor neuron associated with motor neuron diseases
8) Confidence 0.29 Published 1999 Journal No To Shinkei Section Title Doc Link 10396755 Disease Relevance 0.88 Pain Relevance 0
Both patients had elevated polyclonal gamma-globulin levels and rheumatoid factors and, in case 2 an increase of IgG in serum.
Positive_regulation (elevated) of Gene_expression (levels) of gamma-globulin
9) Confidence 0.25 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2176142 Disease Relevance 1.08 Pain Relevance 0.13

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