INT14501

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 25.77
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
cerebrospinal fluid 3
body 2
plasma 1
dorsal 1
liver 1
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 4 99.74 Very High Very High Very High
Spinal cord 5 99.68 Very High Very High Very High
Inflammation 30 98.24 Very High Very High Very High
postherpetic neuralgia 1 97.56 Very High Very High Very High
Neuropathic pain 3 96.32 Very High Very High Very High
IPN 1 95.48 Very High Very High Very High
Angina 21 95.40 Very High Very High Very High
Pain 48 94.76 High High
abdominal pain 1 94.24 High High
Fibrositis 24 93.68 High High
Disease Link Frequency Relevance Heat
Injury 14 100.00 Very High Very High Very High
Cyst 2 99.92 Very High Very High Very High
Pain 46 99.74 Very High Very High Very High
Diabetes Mellitus 202 99.36 Very High Very High Very High
Disease 46 99.32 Very High Very High Very High
Renal Disease 150 98.96 Very High Very High Very High
Malignant Neoplastic Disease 2 98.40 Very High Very High Very High
Atherosclerosis 23 98.36 Very High Very High Very High
Respiratory Failure 3 98.28 Very High Very High Very High
INFLAMMATION 32 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with our previous animal study and the idea that persistent pain induces the synthesis and release of cystatin C in dorsal spinal cord, the surplus of which overflows into the CSF.
Gene_expression (synthesis) of cystatin C in dorsal associated with pain, lasting pain and spinal cord
1) Confidence 0.75 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.56 Pain Relevance 0.64
A recent subtractive cDNA cloning study in rats demonstrated an unexpected increase in expression of the proteinase inhibitor, cystatin C in the spinal cord during acute peripheral inflammation, suggesting this protein may be involved in the pathogenesis of persistent pain.
Gene_expression (expression) of cystatin C in spinal cord associated with pain, inflammation, lasting pain and spinal cord
2) Confidence 0.75 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.70 Pain Relevance 0.70
However, there were no significant differences between the groups in the changes in plasma renin activity, creatinine, and Cystatin-C levels.
Gene_expression (levels) of Cystatin-C in plasma
3) Confidence 0.65 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782157 Disease Relevance 0.27 Pain Relevance 0.03
Cystatin C rose significantly 8 and 24 h after the procedure.
Gene_expression (rose) of Cystatin C
4) Confidence 0.65 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17566573 Disease Relevance 0.33 Pain Relevance 0.07
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
Gene_expression (predict) of cystatin C in neutrophil associated with angina and renal disease
5) Confidence 0.65 Published 2007 Journal Kidney Blood Press. Res. Section Title Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.10
The NGAL levels were significantly higher 2 h after the PCI (serum NGAL) or 4 h after the PCI (urinary NGAL), whereas the cystatin C values were higher only 8 and 24 h after a PCI procedure in patients with CIN.
Gene_expression (values) of cystatin C associated with renal disease
6) Confidence 0.65 Published 2007 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17901710 Disease Relevance 0.55 Pain Relevance 0.07
We used the following effect markers: cystatin C in serum (Dharnidharka et al. 2002) for calculation of glomerular filtration rate (GFR), creatinine clearance as markers of glomerular function, and human complex-forming protein (protein HC, ?
Gene_expression (following) of cystatin C associated with disorders of creatine metabolism
7) Confidence 0.65 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.38 Pain Relevance 0.03
There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase.
Gene_expression (levels) of cystatin C
8) Confidence 0.65 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18362310 Disease Relevance 1.83 Pain Relevance 0.06
Further investigations provided mixed results, on the one hand, cystatin C levels in cerebrospinal fluid appear to be a predictive marker for postherpetic neuralgia in patients with varicella-zoster virus, and a pain marker in women experiencing labour pain, but is not correlated with pain duration or intensity.
Gene_expression (levels) of cystatin C in cerebrospinal fluid associated with pain, herpes zoster and postherpetic neuralgia
9) Confidence 0.65 Published 2009 Journal Clin Drug Investig Section Abstract Doc Link 19445554 Disease Relevance 1.35 Pain Relevance 1.00
In contrast, serum cystatin C levels were higher in diabetic patients (p=0.00001), but not in atherosclerotic subjects (p=0.14), than in the non-involved population after adjustment for age, smoking, and renal function.
Gene_expression (levels) of cystatin C associated with nicotine addiction, atherosclerosis and diabetes mellitus
10) Confidence 0.65 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16140306 Disease Relevance 1.91 Pain Relevance 0.19
A decrease in glomerular filtration rate did not explain higher cystatin-C in cases than in controls.
Neg (not) Gene_expression (explain) of cystatin-C
11) Confidence 0.65 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16046222 Disease Relevance 1.61 Pain Relevance 0.15
Serum cystatin C levels in patients with chronic renal disease are associated with cardiovascular disease mortality and all cause mortality [19], and were shown to predict cardiovascular death, myocardial infarction and stroke in a prospective cohort of adults aged ?
Gene_expression (Serum) of cystatin C associated with stroke, cardiovascular disease, renal disease, myocardial infarction and death
12) Confidence 0.65 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.03 Pain Relevance 0
Analysis of serum cystatin C
Gene_expression (Analysis) of cystatin C
13) Confidence 0.65 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.16 Pain Relevance 0.14
Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
Gene_expression (excretion) of cystatin C in Clara cell associated with weight loss, renal disease and cyst
14) Confidence 0.65 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 0.64 Pain Relevance 0
Serum cystatin C levels in patients with chronic renal disease are associated with cardiovascular disease mortality and all cause mortality [19], and were shown to predict cardiovascular death, myocardial infarction and stroke in a prospective cohort of adults aged ?
Gene_expression (levels) of cystatin C associated with stroke, cardiovascular disease, renal disease, myocardial infarction and death
15) Confidence 0.65 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.03 Pain Relevance 0
Recently, Köttgen et al. [14] published the first genome-wide association study (GWAS) on eGFRcrea, eGFR based on cystatin C (eGFRcys), another measure of kidney function, and CKD, reporting significant association with eGFRcrea at three loci (UMOD, SHROOM3 (GeneID: 57619) and GATM-SPATA5L1 (GeneIDs: 2628 and 79029)), with eGFRcys at two loci (CST3-CST9 (GeneIDs: 1471 and 128822) and STC1 (GeneID: 6781)) and with CKD at one locus (UMOD) [14].
Gene_expression (based) of cystatin C in kidney associated with chronic renal failure
16) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 1.45 Pain Relevance 0
Innovative technologies such as functional genomics and proteomics have facilitated detection of several promising early biomarkers of AKI, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1).
Gene_expression (detection) of cystatin C in liver associated with injury
17) Confidence 0.65 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473256 Disease Relevance 1.01 Pain Relevance 0.16
In preoperative examination, the serum concentrations of gamma-globulin and total protein were 7.31 g x dl(-1) and 11.9 g x dl(-1).
Gene_expression (concentrations) of gamma-globulin
18) Confidence 0.60 Published 2004 Journal Masui Section Abstract Doc Link 15682803 Disease Relevance 0.21 Pain Relevance 0.44
He received intravenous gamma globulin and recovered.
Gene_expression (recovered) of gamma globulin
19) Confidence 0.59 Published 1990 Journal Am. Heart J. Section Abstract Doc Link 1696427 Disease Relevance 0.35 Pain Relevance 0.14
Unlike serum creatinine, for which the serum concentration is strongly affected by muscle mass, cystatin C is produced by all nucleated cells at a constant rate and its serum level is relatively unaffected by age, sex, body composition, diet, and exercise [16,17].
Gene_expression (produced) of cystatin C is in body
20) Confidence 0.58 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.16 Pain Relevance 0

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