INT145018

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 20
Disease Relevance 15.42
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
Anatomy Link Frequency
fat 4
plasma 1
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 85.64 High High
Cholecystokinin 1 70.32 Quite High
cINOD 1 44.32 Quite Low
COX2 2 25.00 Low Low
anesthesia 17 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 2161 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 287 99.92 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

85 99.56 Very High Very High Very High
Obesity 152 99.08 Very High Very High Very High
Disease 230 98.68 Very High Very High Very High
Cardiovascular Disease 140 96.28 Very High Very High Very High
Coronary Artery Disease 130 95.84 Very High Very High Very High
Stroke 66 93.44 High High
INFLAMMATION 20 85.64 High High
Colon Cancer 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither FADS1 nor FADS2 were regulated by rs3737787 genotypes, nor were the expression of these two genes associated with FCHL.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
1) Confidence 0.42 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.92 Pain Relevance 0
One of these modules was also associated with FCHL, the other FCHL component traits, and rs3737787 genotypes.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
2) Confidence 0.42 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.87 Pain Relevance 0
Importantly, some of the genes causally linked to FCHL (ABCC6, AKT2, FADS3, GCLM, HSD11B1) have already been associated with FCHL related traits in humans (Table 3 and Table S8).
FCHL Binding (linked) of associated with familial combined hyperlipidemia
3) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.79 Pain Relevance 0.04
The USF1 gene has previously been associated with a common dyslipidemia, FCHL.
USF1 gene Binding (associated) of associated with familial combined hyperlipidemia
4) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 1.12 Pain Relevance 0
The gender-genotype interaction analysis supports our previous findings for USF1 and SEPS1 variants in which the disease risk was limited to women [30], [31], providing a gender-genotype interaction p-values<0.01 for the USF1 variant rs2774279 and for two SEPS1 variants, rs4965814 and rs9874.
USF1 Binding (findings) of associated with disease
5) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.42 Pain Relevance 0
Other variants of USF1 have also been reported as showing significant gender-genotype interaction for triglycerides and BMI in familial combined hyperlipidemia families [60].
USF1 Binding (interaction) of associated with familial combined hyperlipidemia and obesity
6) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.92 Pain Relevance 0
The association pattern of the tan ME with the FCHL component traits was characteristic of FCHL: elevated plasma levels of TC, TG and ApoB (TC correlation?
FCHL Binding (association) of in plasma associated with familial combined hyperlipidemia and disorder of lipid metabolism
7) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.85 Pain Relevance 0
We first associated rs3737787 genotypes in Mexican Familial Combined Hyperlipidemia (FCHL) case/control fat biopsies, with global expression patterns.
FCHL Binding (associated) of in fat associated with familial combined hyperlipidemia
8) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.55 Pain Relevance 0
Together these data support a causal association between the 18 causal candidate genes from the URFA module and FCHL.
FCHL Binding (association) of associated with familial combined hyperlipidemia
9) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.78 Pain Relevance 0.04
The tan module was the only module to be associated with FCHL, the FCHL component trait signature, and rs3737787 genotypes.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
10) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.95 Pain Relevance 0
One of these modules was also associated with FCHL, the other FCHL component traits, and rs3737787 genotypes.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
11) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.88 Pain Relevance 0
In summary, we demonstrate the function of the rs3737787 LD bin, construct and characterize a co-expression network for Mexican FCHL case/control fat biopsies, and demonstrate that the loci identified as causal can harbor variants associated with FCHL or FCHL component traits.
FCHL Binding (associated) of in fat associated with familial combined hyperlipidemia
12) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.75 Pain Relevance 0
The turquoise module was not significantly associated with FCHL, suggesting that while the expression of turquoise module genes depends on rs3737787 genotypes, the gene functions of the turquoise module are less likely to be related to FCHL (Figure 1, Table S5).
FCHL Binding (associated) of associated with familial combined hyperlipidemia
13) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.85 Pain Relevance 0
In summary, we demonstrate the function of the rs3737787 LD bin, construct and characterize a co-expression network for Mexican FCHL case/control fat biopsies, and demonstrate that the loci identified as causal can harbor variants associated with FCHL or FCHL component traits.
FCHL Binding (associated) of in fat associated with familial combined hyperlipidemia
14) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.75 Pain Relevance 0
We then identified two TG-associated co-expression modules one of which (the URFA module) was also associated with the FCHL, the other FCHL component traits, and rs3737787 genotypes.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
15) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.68 Pain Relevance 0
We then identified two TG-associated co-expression modules one of which (the URFA module) was also associated with the FCHL, the other FCHL component traits, and rs3737787 genotypes.
FCHL Binding (associated) of associated with familial combined hyperlipidemia
16) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.68 Pain Relevance 0
Association for the Mexican FCHL fat biopsy case/control study sample was calculated by regressing genotypes in an additive model to the dichotomized trait of interest using logistic regression with the glm function in R.
FCHL Binding (Association) of in fat associated with familial combined hyperlipidemia
17) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.54 Pain Relevance 0
We tested the co-expression modules for association with FCHL, FCHL component traits, and rs3737787 genotypes.
FCHL Binding (association) of associated with familial combined hyperlipidemia
18) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.70 Pain Relevance 0
We tested the co-expression modules for association with FCHL, FCHL component traits, and rs3737787 genotypes.
FCHL Binding (association) of associated with familial combined hyperlipidemia
19) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.70 Pain Relevance 0
Transcription factors binding to this promoter element were USF-1 und -2.
USF-1 Binding (binding) of
20) Confidence 0.19 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17604853 Disease Relevance 0.26 Pain Relevance 0.04

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