INT14502

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 18.52
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BCHE) extracellular region (BCHE) endoplasmic reticulum (BCHE)
enzyme binding (BCHE)
Anatomy Link Frequency
plasma 11
nervous system 2
cortex 2
brain stem 1
red blood cell 1
BCHE (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 54 100.00 Very High Very High Very High
Morphine 5 99.96 Very High Very High Very High
Enkephalin 2 99.68 Very High Very High Very High
substance P 2 99.22 Very High Very High Very High
Central nervous system 21 97.44 Very High Very High Very High
antagonist 10 95.72 Very High Very High Very High
local anesthetic 2 95.20 Very High Very High Very High
headache 36 94.96 High High
Pain 11 93.64 High High
dexamethasone 260 91.16 High High
Disease Link Frequency Relevance Heat
Disease 280 100.00 Very High Very High Very High
Depression 59 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 3 100.00 Very High Very High Very High
Poisoning 96 99.92 Very High Very High Very High
Cancer 343 99.88 Very High Very High Very High
Toxicity 143 99.24 Very High Very High Very High
Bartter Syndrome 1 98.44 Very High Very High Very High
Cervical Cancer 130 97.80 Very High Very High Very High
Cognitive Disorder 49 96.52 Very High Very High Very High
Emergencies 1 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[The development of cholinesterase activity in the sensitive and motor nuclei of the brain stem in early human embryogenesis].
Gene_expression (activity) of cholinesterase in brain stem
1) Confidence 0.67 Published 1996 Journal Zh. Evol. Biokhim. Fiziol. Section Title Doc Link 8768331 Disease Relevance 0 Pain Relevance 0.07
These irreversible inhibitors of cholinesterase produce three well-recognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilatory care is necessary; and delayed polyneuropathy.
Gene_expression (produce) of cholinesterase associated with neuropathy, emergencies and syndrome
2) Confidence 0.66 Published 1999 Journal Anaesthesia Section Abstract Doc Link 10540097 Disease Relevance 0.48 Pain Relevance 0
By contrast, noticeable qualitative and quantitative discrepancies were observed when hydrolyses of substance P and leucine-enkephalin by these three butyrylcholinesterase pools were studied.
Gene_expression (studied) of butyrylcholinesterase associated with enkephalin and substance p
3) Confidence 0.66 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1696618 Disease Relevance 0 Pain Relevance 0.39
In Sitio Sadag, 51% had cholinesterase levels below the mean value of 0.75–1.0 ?
Gene_expression (levels) of cholinesterase
4) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.09 Pain Relevance 0.05
Table 7 shows the predictors of abnormal RBC cholinesterase levels and abnormal MCV as dependent variables.
Gene_expression (levels) of cholinesterase
5) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0 Pain Relevance 0
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Gene_expression (levels) of cholinesterase in plasma
6) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.60 Pain Relevance 0.04
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Gene_expression (plasma) of cholinesterase in plasma
7) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.59 Pain Relevance 0.04
An even more significant association was found between abnormal RBC cholinesterase levels and selling pesticide containers (p = 0.008).
Gene_expression (levels) of cholinesterase
8) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.80 Pain Relevance 0.04
After performing chi-square analysis to test for independence, significant association was found between selling pesticide containers and abnormal RBC cholinesterase levels (P = 0.001), and mixing of pesticides with abnormal mean corpuscular volume (MCV) (Table 5).
Gene_expression (levels) of cholinesterase
9) Confidence 0.65 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.07 Pain Relevance 0.04
In efficacy experiment, mice were obtained from Charles River Laboratories (Wilmington, MA) and subcutaneous tumors were established by injecting 107 C33A cells into female nu/nu mice. 1×109 vp of Ad5luc1, wild-type, Ad5/3VEGF-E1, RGDCRADcox-2R, Ad5-?
Gene_expression (established) of E1 associated with cancer
10) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.58 Pain Relevance 0.14
A similar but weaker effect was seen with Ad5/3VEGF-E1 (Fig. 5b: 1.5 to 3.5-fold, P?
Gene_expression (fold) of E1
11) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.54 Pain Relevance 0.33
Treatment with oncolytic viruses gave significant therapeutic efficacy in both models (Fig. 3e, f: P<0.0001 for RGDCRADcox-2R, Ad5/3VEGF-E1 or Ad5-?
Gene_expression (/) of E1
12) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.52 Pain Relevance 0.11
Advanced subcutaneous C33A tumors were treated with three intratumoral injections of 1×109 vp of Ad5luc1, wild-type virus, Ad5/3VEGF-E1, RGDCRADcox-2R or Ad5-?
Gene_expression (/) of E1 associated with cancer
13) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.56 Pain Relevance 0.08
Advanced subcutaneous C33A tumors were treated with three intratumoral injections of 1×109 vp of Ad5luc1, wild-type virus, Ad5/3VEGF-E1, RGDCRADcox-2R or Ad5-?
Gene_expression (treated) of E1 associated with cancer
14) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.57 Pain Relevance 0.09
Two patients (x+) appear to have much less severe poisoning as BChE was not depressed.
Neg (not) Gene_expression (depressed) of BChE associated with poisoning
15) Confidence 0.62 Published 2010 Journal J Med Toxicol Section Body Doc Link PMC2996541 Disease Relevance 0.95 Pain Relevance 0
Human butyrylcholinesterase (EC 3.1.1.8) (BChE) is present in serum mainly as "usual UU" form, but it has also been found in variant forms known as "atypical" BChE.
Gene_expression (present) of butyrylcholinesterase
16) Confidence 0.60 Published 2002 Journal Coll Antropol Section Abstract Doc Link 12674844 Disease Relevance 0.22 Pain Relevance 0.07
Human butyrylcholinesterase (EC 3.1.1.8) (BChE) is present in serum mainly as "usual UU" form, but it has also been found in variant forms known as "atypical" BChE.
Gene_expression (present) of BChE
17) Confidence 0.60 Published 2002 Journal Coll Antropol Section Abstract Doc Link 12674844 Disease Relevance 0.22 Pain Relevance 0.07
Red blood cell cholinesterase is the same enzyme that is found in the nervous system, while the plasma cholinesterase also known as butyryl cholinesterase is made in the liver.
Gene_expression (made) of plasma cholinesterase in nervous system
18) Confidence 0.59 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.93 Pain Relevance 0.06
Humans have three types of cholinesterase: red blood cell (RBC) cholinesterase, called "true cholinesterase," plasma cholinesterase, called "pseudo cholinesterase," and brain cholinesterase.
Gene_expression (called) of cholinesterase in plasma
19) Confidence 0.59 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.63 Pain Relevance 0.16
Humans have three types of cholinesterase: red blood cell (RBC) cholinesterase, called "true cholinesterase," plasma cholinesterase, called "pseudo cholinesterase," and brain cholinesterase.
Gene_expression (called) of cholinesterase in plasma
20) Confidence 0.59 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.56 Pain Relevance 0.15

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