INT145045

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 5.37
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Med1) nucleolus (Med1) nucleus (Med1)
DNA binding (Med1) transcription factor binding (Med1)
Anatomy Link Frequency
liver 4
hepatocyte 2
CAR 2
parenchymal cells 1
Med1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 236 70.96 Quite High
Paracetamol 33 60.76 Quite High
Inflammation 367 52.12 Quite High
cytokine 45 34.32 Quite Low
antagonist 32 31.04 Quite Low
addiction 1 25.00 Low Low
Inflammatory response 120 5.00 Very Low Very Low Very Low
Kinase C 120 5.00 Very Low Very Low Very Low
alcohol 60 5.00 Very Low Very Low Very Low
Central nervous system 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 442 99.52 Very High Very High Very High
Hepatocellular Cancer 108 99.16 Very High Very High Very High
Embryonic Lethality 73 97.56 Very High Very High Very High
Repression 60 97.06 Very High Very High Very High
Obesity 337 90.48 High High
Cataract 5 83.16 Quite High
Microphthalmia 5 81.60 Quite High
Congenital Anomalies 5 75.80 Quite High
Liver Cancer 320 73.60 Quite High
Hepatomegaly 61 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DRIP205/TRAP220-deficient embryonic
Gene_expression (deficient) of TRAP220
1) Confidence 0.65 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.31 Pain Relevance 0.07
DRIP205/TRAP220-deficient embryonic
Gene_expression (deficient) of DRIP205
2) Confidence 0.65 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.31 Pain Relevance 0.07
These include CBP/p300, three members of the SRC/p160 family, PBP/MED1 (PPAR-binding protein/TRAP220/DRIP205/mediator subunit 1), PRIP/NCoA6 (ASC2/RAP250/TRBP/NRC) [Zhu et al., 2000a], PRIC285, PRIC295, PRIC320, PGC-1?
Gene_expression (/) of TRAP220
3) Confidence 0.65 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.05 Pain Relevance 0.03
Targeted deletion of coactivator PBP gene in liver parenchymal cells (PBP(LIV-/-)) results in the near abrogation of the induction of PPARalpha and CAR (constitutive androstane receptor)-regulated genes in liver.
Gene_expression (deletion) of coactivator PBP gene in parenchymal cells
4) Confidence 0.53 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.17 Pain Relevance 0
ligand-induced pleiotropic effects, indicating that PBP/MED1 is essential for PPAR?
Gene_expression (/) of PBP
5) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
ligand-induced pleiotropic effects, indicating that PBP/MED1 is essential for PPAR?
Gene_expression (essential) of PBP
6) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
signaling requires PBP/MED1
Gene_expression (/) of PBP
7) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.33 Pain Relevance 0
Conditional deletion of PBP/MED1 gene in liver results in the abrogation of PPAR?
Gene_expression (gene) of MED1 in liver
8) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
These include CBP/p300, three members of the SRC/p160 family, PBP/MED1 (PPAR-binding protein/TRAP220/DRIP205/mediator subunit 1), PRIP/NCoA6 (ASC2/RAP250/TRBP/NRC) [Zhu et al., 2000a], PRIC285, PRIC295, PRIC320, PGC-1?
Gene_expression (/) of PBP
9) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.05 Pain Relevance 0.03
signaling requires PBP/MED1
Gene_expression (signaling) of MED1
10) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.38 Pain Relevance 0
signaling requires PBP/MED1
Gene_expression (signaling) of PBP
11) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.38 Pain Relevance 0
The presence of an occasional PBP/MED1-positive hepatocyte in these livers that escaped Cre-excision provided a characteristic visual contrast, in that such cells displayed the expected response to PPAR?
Gene_expression (excision) of PBP in hepatocyte
12) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.07 Pain Relevance 0
ligand-induced pleiotropic effects, indicating that PBP/MED1 is essential for PPAR?
Gene_expression (essential) of MED1
13) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
ligand-induced pleiotropic effects, indicating that PBP/MED1 is essential for PPAR?
Gene_expression (/) of MED1
14) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
The presence of an occasional PBP/MED1-positive hepatocyte in these livers that escaped Cre-excision provided a characteristic visual contrast, in that such cells displayed the expected response to PPAR?
Gene_expression (excision) of MED1 in hepatocyte
15) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.07 Pain Relevance 0
signaling requires PBP/MED1
Gene_expression (/) of MED1
16) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.33 Pain Relevance 0
Conditional deletion of PBP/MED1 gene in liver results in the abrogation of PPAR?
Gene_expression (gene) of PBP in liver
17) Confidence 0.47 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
The degree of expression of different coactivator proteins such as PBP/MED1, and the particular milieu of coactivators expressed in a particular tissue, organism, or species may therefore also contribute to the variable species response to treatment with PPAR?
Gene_expression (expression) of MED1
18) Confidence 0.42 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0
The degree of expression of different coactivator proteins such as PBP/MED1, and the particular milieu of coactivators expressed in a particular tissue, organism, or species may therefore also contribute to the variable species response to treatment with PPAR?
Gene_expression (expression) of PBP
19) Confidence 0.42 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0
ligand-induced liver cell proliferation was abolished in PBP/MED1 null hepatocytes and in these livers, residual PBP/MED1-expressing cells displayed a proliferative advantage [Jia et al., 2004; Matsumoto et al., 2007].
Gene_expression (expressing) of MED1 in livers
20) Confidence 0.42 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0

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