INT14506

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 9
Speculated 2
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 15.02
Pain Relevance 22.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
colon 3
duodenum 3
dorsal 2
cerebral cortex 2
dendrites 1
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 533 100.00 Very High Very High Very High
substance P 94 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
intrathecal 4 100.00 Very High Very High Very High
Inflammation 31 99.98 Very High Very High Very High
Cholecystokinin 5 99.92 Very High Very High Very High
bradykinin 10 99.88 Very High Very High Very High
antagonist 59 99.80 Very High Very High Very High
Clonidine 6 99.76 Very High Very High Very High
Analgesic 3 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 41 100.00 Very High Very High Very High
Stress 14 100.00 Very High Very High Very High
INFLAMMATION 25 99.98 Very High Very High Very High
Diabetes Mellitus 59 99.64 Very High Very High Very High
Infection 11 99.56 Very High Very High Very High
Gallbladder Neoplasms 94 99.40 Very High Very High Very High
Adenoma 59 98.00 Very High Very High Very High
Bordatella Infection 5 97.24 Very High Very High Very High
Cluster Headache 14 96.80 Very High Very High Very High
Urological Neuroanatomy 7 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of somatostatin and its antagonist on morphine analgesia in mice.
Regulation (Effect) of somatostatin associated with antagonist, somatostatin, analgesia and morphine
1) Confidence 0.62 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 11189195 Disease Relevance 0 Pain Relevance 0.58
AIM: To study the effects of somatostatin (SST) and its antagonist cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr [Bzl]) (SSA) on morphine-induced analgesia.
Regulation (effects) of SST associated with antagonist, somatostatin, analgesia and morphine
2) Confidence 0.62 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 11189195 Disease Relevance 0 Pain Relevance 0.52
In this study, we have used the mouse intestine and the Ussing short circuit technique to compare the effects and mechanism of action of somatostatin (SST, 0.1 microM) on cAMP- and Ca(2+)-mediated ion secretion in the duodenum and colon of the Swiss-Webster mouse.
Regulation (effects) of somatostatin in duodenum associated with somatostatin
3) Confidence 0.45 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.09
Effect of somatostatin on electrogenic ion transport in the duodenum and colon of the mouse, Mus domesticus.
Regulation (Effect) of somatostatin in duodenum associated with somatostatin
4) Confidence 0.45 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Title Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.15
AIM: To study the effects of somatostatin (SST) and its antagonist cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr [Bzl]) (SSA) on morphine-induced analgesia.
Regulation (effects) of somatostatin associated with antagonist, somatostatin, analgesia and morphine
5) Confidence 0.45 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 11189195 Disease Relevance 0 Pain Relevance 0.52
However, the level of somatostatin was not significantly altered in mice diabetic for either 2 weeks or 8 weeks.
Neg (not) Regulation (altered) of somatostatin associated with diabetes mellitus and somatostatin
6) Confidence 0.45 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1719570 Disease Relevance 0.83 Pain Relevance 0.36
Effect of somatostatin on gastrointestinal contractility in Schistosoma mansoni infected mice.
Regulation (Effect) of somatostatin associated with somatostatin
7) Confidence 0.45 Published 2002 Journal Int. J. Parasitol. Section Title Doc Link 12204231 Disease Relevance 1.07 Pain Relevance 0.38
This study was designed to evaluate both the vascular effect of SRIF on the dorsal hand vein and SRIF plasma levels prior to and after subcutaneous and intranasal administration in CH patients.
Regulation (effect) of SRIF in dorsal associated with cluster headache and somatostatin
8) Confidence 0.45 Published 1987 Journal Ric Clin Lab Section Abstract Doc Link 2888182 Disease Relevance 0.77 Pain Relevance 1.14
The effects of cold water swim stress (CWSS) on the nociceptive responses to i.t. administered substance P (SP) and somatostatin (SST) were examined.
Regulation (effects) of somatostatin associated with nociception, stress, somatostatin and substance p
9) Confidence 0.44 Published 1993 Journal Life Sci. Section Abstract Doc Link 7681927 Disease Relevance 0.96 Pain Relevance 0.55
To understand the mechanism underlying this enhancement by prior noxious stimuli, we examined the effects of intrathecal (i.t.) injection of substance P (SP) and somatostatin (SOM) on autotomy behavior.
Spec (examined) Regulation (effects) of somatostatin associated with somatostatin, substance p and intrathecal
10) Confidence 0.44 Published 1996 Journal Pain Section Abstract Doc Link 8867259 Disease Relevance 0.14 Pain Relevance 0.74
These agents did not alter Bay K 8644-evoked Ca+(+) influx or did they affect the ability of SRIF to inhibit Ca+(+) influx.
Regulation (affect) of SRIF associated with somatostatin
11) Confidence 0.43 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1696631 Disease Relevance 0.09 Pain Relevance 0.94
Effects of intrathecal (i.t.) somatostatin (SST) on nociception, motor function, and spinal cord pathology were evaluated in cats and mice.
Regulation (Effects) of somatostatin in spinal cord associated with nociception, somatostatin, spinal cord and intrathecal
12) Confidence 0.42 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2566288 Disease Relevance 0.23 Pain Relevance 0.56
The effects of cold water swim stress (CWSS) on the nociceptive responses to i.t. administered substance P (SP) and somatostatin (SST) were examined.
Regulation (effects) of SST associated with nociception, stress, somatostatin and substance p
13) Confidence 0.41 Published 1993 Journal Life Sci. Section Abstract Doc Link 7681927 Disease Relevance 0.97 Pain Relevance 0.56
Striatal somatostatin levels were unchanged.
Neg (unchanged) Regulation (unchanged) of somatostatin associated with somatostatin
14) Confidence 0.40 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630562 Disease Relevance 0.73 Pain Relevance 0.80
In this study, we have used the mouse intestine and the Ussing short circuit technique to compare the effects and mechanism of action of somatostatin (SST, 0.1 microM) on cAMP- and Ca(2+)-mediated ion secretion in the duodenum and colon of the Swiss-Webster mouse.
Regulation (effects) of SST in duodenum associated with somatostatin
15) Confidence 0.40 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.09
In addition, we noticed that such a high SST concentration did not affect the growth of gallbladder cancer xenografts on nude mice.
Neg (not) Regulation (affect) of SST associated with gallbladder neoplasms and somatostatin
16) Confidence 0.39 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.62 Pain Relevance 0.45
SST has been used as a regulator of secretion of many gastrointestinal hormones in the clinic for a long time.
Regulation (regulator) of SST associated with somatostatin
17) Confidence 0.39 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.90 Pain Relevance 0.38
This study was designed to evaluate both the vascular effect of SRIF on the dorsal hand vein and SRIF plasma levels prior to and after subcutaneous and intranasal administration in CH patients.
Regulation (effect) of SRIF in dorsal associated with cluster headache and somatostatin
18) Confidence 0.39 Published 1987 Journal Ric Clin Lab Section Abstract Doc Link 2888182 Disease Relevance 0.78 Pain Relevance 1.16
To understand the mechanism underlying this enhancement by prior noxious stimuli, we examined the effects of intrathecal (i.t.) injection of substance P (SP) and somatostatin (SOM) on autotomy behavior.
Spec (examined) Regulation (effects) of SOM associated with somatostatin, substance p and intrathecal
19) Confidence 0.39 Published 1996 Journal Pain Section Abstract Doc Link 8867259 Disease Relevance 0.14 Pain Relevance 0.74
Twelve weeks after infection of C57BL/6J mice with LP-BM5, significant (50-60%) reductions in Met-enkephalin and substance P levels were observed in the striatum, whereas somatostatin levels were unchanged.
Neg (unchanged) Regulation (unchanged) of somatostatin in striatum associated with somatostatin, enkephalin, infection and substance p
20) Confidence 0.39 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534338 Disease Relevance 0.49 Pain Relevance 0.43

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