INT145074

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.56
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC22A5) transmembrane transport (SLC22A5)
SLC22A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 13 96.08 Very High Very High Very High
Crohn's disease 37 94.80 High High
Bioavailability 1 83.60 Quite High
Inflammation 13 63.92 Quite High
anticonvulsant 1 51.36 Quite High
Central nervous system 1 25.00 Low Low
addiction 1 25.00 Low Low
Bile 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 1 99.90 Very High Very High Very High
Disease 57 94.48 High High
Primary Sclerosing Cholangitis 21 81.52 Quite High
Biliary Liver Cirrhosis 15 78.72 Quite High
Colitis 2 70.72 Quite High
Inflammatory Bowel Disease 21 70.40 Quite High
INFLAMMATION 11 55.20 Quite High
Neuropathic Pain 1 53.80 Quite High
Epilepsy 1 52.92 Quite High
Autoimmune Disease 2 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its function as carnitine transporter, novel organic cation transporter type 2 (OCTN2; human gene symbol SLC22A5) is widely recognized as a transporter of drugs.
OCTN2 Binding (recognized) of
1) Confidence 0.37 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 18981167 Disease Relevance 0 Pain Relevance 0.06
We confirmed a strong association between three NOD2/CARD15 gene variants (Pro268Ser, OR = 2.52, 95% CI = 1.34 – 4.75); (Arg702Trp, OR = 6.65, 95% CI = 1.99 – 22.17); (1007fs, OR = 9.59, 95% CI = 3.94 – 23.29), and a weak association between both the protective OCTN1/OCTN2 CC haplotype (OR = 0.28, 95% CI = 0.08 – 0.94), and a variant of ATG16L1 gene (Thr300Ala, OR = 0.468, 95% CI = 0.24 – 0.90) with Crohn's disease.
OCTN2 Binding (association) of associated with crohn's disease and disease
2) Confidence 0.25 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2535589 Disease Relevance 1.35 Pain Relevance 0.25
Creatinine clearance and OCTN1 genotype accounted for 56% of the variation in CL(R) and were the only significant predictors of CL(R) (P<0.05).
OCTN1 Binding (accounted) of associated with disorders of creatine metabolism
3) Confidence 0.04 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17609685 Disease Relevance 0.21 Pain Relevance 0.98

General Comments

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