INT145075

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC22A5) transmembrane transport (SLC22A5)
SLC22A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 24 99.84 Very High Very High Very High
Bioavailability 2 97.52 Very High Very High Very High
anticonvulsant 2 46.08 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 2 94.52 High High
Neuropathic Pain 2 48.52 Quite Low
Epilepsy 2 47.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that OCTN1 contributes to active tubular secretion of gabapentin, and that this effect may be diminished or absent in individuals carrying the OCTN1-L503F polymorphism.
Localization (secretion) of OCTN1 associated with gabapentin
1) Confidence 0.08 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17609685 Disease Relevance 0.09 Pain Relevance 0.83
Importantly, OCTN1 genotype was the only significant predictor of net secretion of gabapentin (P<0.008).
Localization (secretion) of OCTN1 associated with gabapentin
2) Confidence 0.08 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17609685 Disease Relevance 0.09 Pain Relevance 0.92

General Comments

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