INT145097

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 19.11
Pain Relevance 16.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
arm 2
forceps 1
midline 1
Pain1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1049 100.00 Very High Very High Very High
Neuropathic pain 97 100.00 Very High Very High Very High
depression 46 100.00 Very High Very High Very High
painful pain 14 100.00 Very High Very High Very High
Somatic pain 4 99.84 Very High Very High Very High
Analgesic 88 99.56 Very High Very High Very High
Osteoarthritis 32 99.28 Very High Very High Very High
Painful diabetic neuropathy 56 99.18 Very High Very High Very High
Duloxetine 588 99.06 Very High Very High Very High
Lasting pain 58 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1112 100.00 Very High Very High Very High
Neuropathic Pain 153 100.00 Very High Very High Very High
Diabetes Mellitus 84 100.00 Very High Very High Very High
Depression 59 100.00 Very High Very High Very High
Nociception 38 100.00 Very High Very High Very High
Reprotox - General 3 20 100.00 Very High Very High Very High
Hyperglycemia 14 100.00 Very High Very High Very High
Incontinence 58 99.96 Very High Very High Very High
Osteoarthritis 30 99.28 Very High Very High Very High
Diabetic Neuropathy 105 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Natural diversity of Pain-1 cDNA alleles
Negative_regulation (diversity) of Pain-1 associated with pain
1) Confidence 0.22 Published 2010 Journal BMC Plant Biol Section Body Doc Link PMC3012049 Disease Relevance 0.58 Pain Relevance 0.49
Figure 2 shows that in all 3 trials, subjects in the duloxetine 60 mg qd or 60 mg bid treatment arm reported a greater decrease in 24-hour average pain severity relative to placebo after the first week and this effect was maintained throughout the 12-week dosing period.
Negative_regulation (decrease) of pain in arm associated with pain and duloxetine
2) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.28 Pain Relevance 1.16
In the Goldstein et al (2005) trial, subjects in the 20 mg arm did not show significant pain reduction relative to placebo.
Negative_regulation (reduction) of pain in arm associated with pain
3) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.25 Pain Relevance 1.17
Due to its dual effects on 5-HT and NE reuptake, duloxetine has also been studied and approved for use in reducing diabetic neuropathic pain.
Negative_regulation (reducing) of pain associated with diabetes mellitus, neuropathic pain and duloxetine
4) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.19 Pain Relevance 0.96
Figure 2 also shows that in all 3 studies, the reduction in 24-hour average pain severity was consistent with a dose dependent response.


Negative_regulation (reduction) of pain associated with pain
5) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.25 Pain Relevance 1.15
Accordingly, one can easily understand how patients with painful diabetic neuropathy begin to slip into a downward spiral of decreasing physical activity, depression, poor self-care, worsening hyperglycemia, and progressive neuropathic pain.
Negative_regulation (decreasing) of pain associated with hyperglycemia, painful diabetic neuropathy, depression and neuropathic pain
6) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.13 Pain Relevance 0.80
Duloxetine has been studied extensively in pre-clinical animal models of both persistent neuropathic pain and acute nociceptive pain.
Negative_regulation (nociceptive) of pain associated with nociception, neuropathic pain, painful pain and duloxetine
7) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 0.72 Pain Relevance 1.37
In chronic diabetic neuropathic pain, the functionality of these descending pain inhibition pathways may be reduced, further amplifying pain perception.
Negative_regulation (reduced) of pain associated with pain, diabetes mellitus and neuropathic pain
8) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.58 Pain Relevance 1.76
CONCLUSIONS: Findings suggest that, at least at a 6-week follow up: (1) deep ketamine therapy is effective for relief of pain CRPS I and (2) there were no adverse cognitive effects of extended treatment with deep ketamine infusion.
Negative_regulation (relief) of pain CRPS I
9) Confidence 0.05 Published 2007 Journal Arch Clin Neuropsychol Section Body Doc Link 17611073 Disease Relevance 0.06 Pain Relevance 0
Mechanical thresholds for pain are decreased in patients with osteoarthritis or rheumatoid arthritis [59].
Negative_regulation (decreased) of pain associated with pain, rheumatoid arthritis and osteoarthritis
10) Confidence 0.05 Published 2007 Journal Mol Pain Section Body Doc Link PMC1851005 Disease Relevance 1.59 Pain Relevance 1.28
Pain was defined as and limited to somatic pain, i.e. a symptom generally relieved by analgesics, and consequently excluding what the pain expert interpreted as existential pain.


Negative_regulation (limited) of Pain associated with pain, analgesic and somatic pain
11) Confidence 0.04 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.21 Pain Relevance 1.01
That both mediolateral episiotomy and midline episiotomy are independent risk factors for incident cases of urinary incontinence, anal incontinence, persisting perineal pain and sexual problems after spontaneous vaginal birth.
Negative_regulation (persisting) of pain in midline associated with pain, reprotox - general 3 and incontinence
12) Confidence 0.03 Published 2006 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1463006 Disease Relevance 1.34 Pain Relevance 0.43
That vaginal birth assisted by forceps or vacuum extraction is an independent risk factor for incident cases of urinary incontinence, anal incontinence, persisting perineal pain and sexual problems after birth.
Negative_regulation (persisting) of pain in forceps associated with pain, reprotox - general 3 and incontinence
13) Confidence 0.03 Published 2006 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1463006 Disease Relevance 1.15 Pain Relevance 0.36
Pain should be prevented whenever possible, and in case of chronic pain analgesics should be administered according to a time programming, and not as needed.
Spec (possible) Negative_regulation (prevented) of Pain associated with pain, analgesic and lasting pain
14) Confidence 0.03 Published 2009 Journal The Open Biochemistry Journal Section Body Doc Link PMC2695605 Disease Relevance 1.03 Pain Relevance 1.75
Unrelieved pain places a heavy burden on children and families, and also on medical structures:
       Children become afraid of actual and future pain, and develop mistrust and fear of hospitals, medical staff and treatment procedures.Parents and other relatives often feel angry and distrustful towards the medical system, and experience depression and guilt about being unable to prevent the pain.Poorly managed pain affects health careworkers: it numbs their compassion, creates guilt, and encourages denial that children are suffering.

Negative_regulation (prevent) of pain associated with phobia, pain and depression
15) Confidence 0.02 Published 2009 Journal The Open Biochemistry Journal Section Body Doc Link PMC2695605 Disease Relevance 1.36 Pain Relevance 0.93
The first is that pain must be prevented in each of its various aspects whenever possible.
Negative_regulation (prevented) of pain associated with pain
16) Confidence 0.02 Published 2009 Journal The Open Biochemistry Journal Section Body Doc Link PMC2695605 Disease Relevance 1.57 Pain Relevance 1.31
Neurobiology of Pain in Children: An Overview

The evaluation of pain in the newborn and the infant is difficult because pain is mainly a subjective phenomenon.

Negative_regulation (Neurobiology) of Pain associated with pain
17) Confidence 0.02 Published 2009 Journal The Open Biochemistry Journal Section Title Doc Link PMC2695605 Disease Relevance 0.82 Pain Relevance 0.89

General Comments

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