INT145099

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 4
hippocampus 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
Hippocampus 20 99.46 Very High Very High Very High
Glutamate 3 85.84 High High
Analgesic 2 58.92 Quite High
anticonvulsant 2 58.48 Quite High
medulla 17 54.64 Quite High
Central nervous system 1 8.76 Low Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 25 96.40 Very High Very High Very High
Drug Induced Neurotoxicity 1 95.28 Very High Very High Very High
Stress 11 75.00 Quite High
Disease 4 66.04 Quite High
Anaerobic Bacterial Infections 2 62.40 Quite High
Vertigo 2 61.88 Quite High
Epilepsy 2 61.52 Quite High
Neurosyphilis 2 61.12 Quite High
Alzheimer's Dementia 8 38.00 Quite Low
Neurodegenerative Disease 3 21.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Neg (unchanged) Regulation (unchanged) of Transcription (expression) of nNOS in neuronal associated with neuronal nitric oxide synthase
1) Confidence 0.44 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Neg (unchanged) Regulation (unchanged) of Transcription (levels) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.44 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
In this sense, it has been reported that: 1- different regions behave differently during aging and/or degeneration [16]; 2- nNOS expression and synthesis can be regulated by Ca2+fluxes independently from nNOS activity especially in the hippocampus [24]; (c) there is a post-transcriptional regulation of nNOS expression in the brain of SAM [17].
Regulation (regulation) of Transcription (transcriptional) of nNOS in hippocampus associated with aging and hippocampus
3) Confidence 0.23 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.32 Pain Relevance 0.25

General Comments

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