INT14510

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Context Info
Confidence 0.76
First Reported 1988
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 208
Total Number 212
Disease Relevance 88.56
Pain Relevance 12.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
liver 6
eye 6
lung 6
SH-SY5Y 5
lateral 4
SOD1 (Homo sapiens)
SOD1 - G93A (9)
Pain Link Frequency Relevance Heat
Dismenorea 37 99.96 Very High Very High Very High
agonist 414 99.66 Very High Very High Very High
endometriosis 264 99.64 Very High Very High Very High
Hippocampus 234 99.60 Very High Very High Very High
Inflammation 929 99.32 Very High Very High Very High
long-term potentiation 25 98.52 Very High Very High Very High
cINOD 40 98.16 Very High Very High Very High
Paracetamol 44 97.80 Very High Very High Very High
Spinal cord 89 97.44 Very High Very High Very High
Osteoarthritis 61 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1927 100.00 Very High Very High Very High
Motor Neuron Diseases 1027 100.00 Very High Very High Very High
Neuroblastoma 582 100.00 Very High Very High Very High
Targeted Disruption 488 100.00 Very High Very High Very High
Toxicity 316 100.00 Very High Very High Very High
Seronegative Spondarthritis 20 100.00 Very High Very High Very High
Obesity 153 99.96 Very High Very High Very High
Myocardial Infarction 69 99.96 Very High Very High Very High
Dysmenorrhea 7 99.96 Very High Very High Very High
Parkinson's Disease 68 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOD1 activity of blank HSA NP-treated cells was also evaluated as a control to study the effect of the vector alone on SOD1 expression.
Gene_expression (expression) of SOD1
1) Confidence 0.76 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
The cytotoxicity of EUG was significantly enhanced by high concentrations of NAC or GSH, which may be attributed to the inhibition of SOD mRNAs expression by the synergistic action of EUG and GSH or NAC.
Gene_expression (expression) of SOD
2) Confidence 0.75 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.28 Pain Relevance 0
The expression of the mRNAs for MnSOD and Cu/ZnSOD in HL-60 cells, as assessed by RT-PCR, was significantly inhibited by treatment with 1 mM EUG for 1 hour.
Gene_expression (expression) of SOD in HL-60
3) Confidence 0.75 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.26 Pain Relevance 0
Expression of superoxide dismutase (SOD) in adenomyosis.
Gene_expression (Expression) of SOD associated with dismenorea
4) Confidence 0.75 Published 1993 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 8372889 Disease Relevance 0.10 Pain Relevance 0.19
Transgenic flies expressing increased Cu/ZnSOD and catalase [22] displayed extended lifespan.
Gene_expression (expressing) of SOD associated with targeted disruption and lifespan
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637430 Disease Relevance 1.16 Pain Relevance 0
SOD activity was expressed in international units (U).


Gene_expression (expressed) of SOD
6) Confidence 0.74 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.40 Pain Relevance 0
Transfected human neuroblastoma cell lines expressing either wild-type (Wt) human SOD1 or the G93A mutant of this enzyme associated with familial amyotrophic lateral sclerosis (FALS) were produced by MTC.
Gene_expression (expressing) of SOD1 in lateral associated with neuroblastoma and motor neuron diseases
7) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.43 Pain Relevance 0.03
The anti-oxidant N-acetylcysteine has been shown to restore mitochondrial function and to lower the production of reactive oxygen species in neuroblastoma cells expressing mutant SOD1 [34].
Gene_expression (expressing) of SOD1 associated with neuroblastoma
8) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.69 Pain Relevance 0.06
Neuronal cells expressing a SOD1 mutant frequently encountered in familial cases of amyotrophic lateral sclerosis are more vulnerable to the direct action of the bacterial hemolysin pneumolysin and to the attack of activated immune cells than neuronal cells expressing wild-type SOD1.
Gene_expression (expressing) of SOD1 in immune cells associated with motor neuron diseases
9) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.47 Pain Relevance 0.07
The present study shows that the expression levels of genes displaying antioxidant and cytoprotective properties, such as SOD-1, SOD-2, and HO-1, are depressed in lung cancer as compared to the unaffected lung tissue.
Gene_expression (expression) of SOD in lung associated with lung cancer
10) Confidence 0.72 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.45 Pain Relevance 0
The present study shows that the expression levels of genes displaying antioxidant and cytoprotective properties, such as SOD-1, SOD-2, and HO-1, are depressed in lung cancer as compared to the unaffected lung tissue.
Gene_expression (expression) of SOD in lung associated with lung cancer
11) Confidence 0.72 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.46 Pain Relevance 0
Previous studies investigating on SOD expression in human lung cancer produced variable results (reviewed in [20]).
Gene_expression (expression) of SOD in lung associated with lung cancer
12) Confidence 0.72 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.40 Pain Relevance 0
METHODOLOGY: Immunohistochemical analysis for manganese SOD, copper/zinc SOD, catalase, and glutathione peroxidase expression using the avidin-biotin-peroxidase complex method was performed on pancreatic specimens previously fixed in formalin and embedded in paraffin.
Gene_expression (expression) of SOD
13) Confidence 0.69 Published 2003 Journal Pancreas Section Body Doc Link 12499913 Disease Relevance 0 Pain Relevance 0
A transgenic mouse overexpressing human SOD1 was created and may serve as a model for neurodegenerative disorders [9].
Gene_expression (overexpressing) of SOD1 associated with targeted disruption and neurodegenerative disease
14) Confidence 0.68 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.81 Pain Relevance 0.17
The findings of absent human SOD1 in the wild types, comparable expression in hemizygous, and significantly higher levels in homozygous SOD1-TGs biochemically and biologically characterises and defines this mouse model.
Gene_expression (expression) of SOD1
15) Confidence 0.68 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.09 Pain Relevance 0.08
It has been reported that hippocampal slices from transgenic mice overexpressing SOD1 (SOD1-TG) were found to exhibit deficient long-term potentiation, a putative neural substrate of memory, and hippocampal-mediated memory function [10].
Gene_expression (overexpressing) of SOD1 in neural associated with targeted disruption and long-term potentiation
16) Confidence 0.68 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.77 Pain Relevance 0.18
It has been reported that hippocampal slices from transgenic mice overexpressing SOD1 (SOD1-TG) were found to exhibit deficient long-term potentiation, a putative neural substrate of memory, and hippocampal-mediated memory function [10].
Gene_expression (overexpressing) of SOD1 in neural associated with targeted disruption and long-term potentiation
17) Confidence 0.68 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.77 Pain Relevance 0.18
Moreover, no obvious correlation between protein instability and aggregation propensity was observed for the SOD1 variants used in Figure 3 (Figure S1), indicating that increased instability is not responsible for the increased predicted protein aggregation propensity.
Gene_expression (variants) of SOD1
18) Confidence 0.67 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.09 Pain Relevance 0
The instability values for SOD1 variants were obtained from the equation normalized instability = 1 – average of normalized ??
Gene_expression (variants) of SOD1
19) Confidence 0.67 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0
These results indicate that changes in the SOD1 variants' properties, specifically increases in hydrophobicity and propensity to lose ?
Gene_expression (variants) of SOD1
20) Confidence 0.67 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0

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