INT145100

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
neuronal 4
endothelial cell 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
Bioavailability 2 97.04 Very High Very High Very High
Inflammation 42 70.64 Quite High
ischemia 3 60.40 Quite High
Analgesic 2 58.92 Quite High
anticonvulsant 2 58.48 Quite High
Tetrahydrobiopterin 5 54.64 Quite High
COX-2 inhibitor 2 37.56 Quite Low
cva 16 5.00 Very Low Very Low Very Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 9 96.56 Very High Very High Very High
Stress 73 96.16 Very High Very High Very High
Atherosclerosis 34 92.16 High High
Disease 26 84.48 Quite High
INFLAMMATION 46 70.64 Quite High
Diabetes Mellitus 145 63.48 Quite High
Anaerobic Bacterial Infections 2 62.40 Quite High
Vertigo 2 61.88 Quite High
Epilepsy 6 61.52 Quite High
Neurosyphilis 2 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Neg (unchanged) Regulation (unchanged) of Transcription (expression) of eNOS in neuronal associated with neuronal nitric oxide synthase
1) Confidence 0.44 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Neg (unchanged) Regulation (unchanged) of Transcription (expression) of endothelial nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.44 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
Regulation (regulation) of Transcription (expression) of eNOS in endothelial cell associated with hyperglycemia and stress
3) Confidence 0.24 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.90 Pain Relevance 0.10
Statins restore NO production by several mechanisms, including up-regulation of eNOS mRNA and protein levels and preservation of NO inactivation by reactive oxygen species.
Regulation (regulation) of Transcription (levels) of eNOS
4) Confidence 0.15 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox