INT145101

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 6.04
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
neuronal 4
spinal cord 2
endothelial cell 1
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 4 99.76 Very High Very High Very High
Spinal cord 106 99.68 Very High Very High Very High
Sciatic nerve 154 98.28 Very High Very High Very High
Hippocampus 25 97.64 Very High Very High Very High
Bioavailability 2 96.48 Very High Very High Very High
Thermal hyperalgesia 32 94.68 High High
allodynia 62 93.40 High High
Neuropathic pain 44 82.96 Quite High
Pain 17 78.72 Quite High
Inflammation 46 70.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 202 99.04 Very High Very High Very High
Hyperglycemia 9 96.28 Very High Very High Very High
Nervous System Injury 64 95.96 Very High Very High Very High
Stress 77 95.88 Very High Very High Very High
Hyperalgesia 34 94.68 High High
Neuropathic Pain 111 93.40 High High
Atherosclerosis 34 92.16 High High
Syndrome 9 89.84 High High
Influenza Virus Infection 28 89.80 High High
Disease 32 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (expression) of endothelial nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
1) Confidence 0.70 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (expression) of eNOS in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.70 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
The mRNA and protein levels of NOS1, NOS2 and NOS3 in the spinal cord of WT and KO mice, at 21 days after surgery, were also assessed.
Transcription (levels) of NOS3 in spinal cord associated with targeted disruption and spinal cord
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.80 Pain Relevance 1.00
The relative mRNA levels of NOS3 gene in the spinal cord from sham-operated and sciatic nerve-injured WT, NOS2-KO and NOS1-KO mice are shown in Fig. 4A.
Transcription (levels) of NOS3 gene in spinal cord associated with targeted disruption, sciatic nerve and spinal cord
4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.96 Pain Relevance 0.57
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (levels) of eNOS in neuronal associated with neuronal nitric oxide synthase
5) Confidence 0.52 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (levels) of endothelial nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
6) Confidence 0.52 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
On the contrary, no differences in NOS-1 or NOS-3 mRNA levels were found between infected and control mice.
Transcription (levels) of NOS-3
7) Confidence 0.33 Published 2007 Journal Neurochem Res Section Abstract Doc Link PMC2295255 Disease Relevance 0.32 Pain Relevance 0.17
Statins restore NO production by several mechanisms, including up-regulation of eNOS mRNA and protein levels and preservation of NO inactivation by reactive oxygen species.
Transcription (levels) of eNOS
8) Confidence 0.30 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.22 Pain Relevance 0.08
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
Transcription (expression) of eNOS in endothelial cell associated with hyperglycemia and stress
9) Confidence 0.28 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.90 Pain Relevance 0.10

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