INT145122

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) signal transduction (Oprm1) nucleus (Msh3)
plasma membrane (Oprm1) enzyme binding (Msh3) DNA binding (Msh3)
Anatomy Link Frequency
neurons 1
Oprm1 (Mus musculus)
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
gABA 7 98.04 Very High Very High Very High
GABAergic 1 95.76 Very High Very High Very High
Opioid 1 94.56 High High
Action potential 1 73.76 Quite High
Glutamate 2 64.40 Quite High
antagonist 1 25.04 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 89.00 High High
Infection 1 56.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endogenous selective MOR agonist endomorphin-1 (EM-1) reduced spontaneous and evoked excitatory postsynaptic currents (EPSCs) and inhibitory postsynaptic currents (IPSCs) in both rat and mouse DMV neurons.
MOR Negative_regulation (reduced) of EM-1 in neurons associated with agonist and opioid receptor
1) Confidence 0.06 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17615134 Disease Relevance 0.15 Pain Relevance 0.63

General Comments

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