INT145126

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 4.55
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GLRX) transport (GLRX) small molecule metabolic process (GLRX)
cytoplasm (GLRX)
Anatomy Link Frequency
liver 3
paw 2
MKGS 1
GLRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 98.16 Very High Very High Very High
Analgesic 30 94.20 High High
carrageenan induced 1 72.52 Quite High
Pain 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 27 99.82 Very High Very High Very High
INFLAMMATION 32 98.16 Very High Very High Very High
Necrosis 1 82.12 Quite High
Cancer 1 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection.
Positive_regulation (increased) of GRx in paw associated with pressure and volume under development and inflammation
1) Confidence 0.12 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.84 Pain Relevance 0.55
The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.
Positive_regulation (increasing) of GRx in liver associated with pressure and volume under development and inflammation
2) Confidence 0.12 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.86 Pain Relevance 0.52
FL and FM significantly increased the GRx and GPx activities in the liver and decreased the levels of malondialdehyde (MDA) and nitric oxide (NO) in the edema paw (p < 0.001).
Positive_regulation (increased) of GRx in liver associated with pressure and volume under development
3) Confidence 0.08 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.89 Pain Relevance 0.46
The anti-inflammatory mechanism of FL and FM might be related to the decrease in the level of MDA in the edema paw via increasing the activities of GPx and GRx in the liver and decreasing the NO level in the edema paw.
Positive_regulation (increasing) of GRx in paw associated with pressure and volume under development and inflammation
4) Confidence 0.08 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.91 Pain Relevance 0.42
The anti-inflammatory mechanism of WET might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.


Positive_regulation (increasing) of GRx in liver
5) Confidence 0.06 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19703536 Disease Relevance 0 Pain Relevance 0
Furthermore, MKGS increased the activities of SOD and GRx in liver tissues and decreased MDA level in the edema paws three hours after lambda-carrageenan was injected.
Positive_regulation (increased) of GRx in MKGS associated with pressure and volume under development
6) Confidence 0.02 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 1.05 Pain Relevance 0.57

General Comments

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