INT145128

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.59
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc6) plasma membrane (Trpc6) transmembrane transport (Trpc6)
Anatomy Link Frequency
podocyte 3
neuronal 1
cerebrum 1
skeletal muscle 1
heart 1
Trpc6 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 12 100.00 Very High Very High Very High
Calcium channel 3 96.92 Very High Very High Very High
member 8 5 95.68 Very High Very High Very High
TRP channel 301 90.08 High High
Cancer pain 2 50.96 Quite High
imagery 1 49.00 Quite Low
cytokine 1 30.88 Quite Low
glial activation 1 27.68 Quite Low
Pain 6 17.68 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 3 99.76 Very High Very High Very High
Aggression 1 99.12 Very High Very High Very High
Apoptosis 30 98.72 Very High Very High Very High
Cancer 12 98.20 Very High Very High Very High
Sprains And Strains 102 93.24 High High
Reprotox - General 1 4 92.00 High High
Adhesions 3 76.60 Quite High
Nephrotic Syndrome 8 73.96 Quite High
Death 7 57.68 Quite High
Necrosis 1 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the enhancement expression of TRPC6 as well as the increased Ca(2+) influx mediated by TRPC6 channels contributed to the podocyte apoptosis.
Gene_expression (expression) of TRPC6 in podocyte associated with apoptosis
1) Confidence 0.75 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.65 Pain Relevance 0.09
The present study evaluated the alteration of TRPC6 expression and the Ca(2+) influx involved in Ang II-induced podocyte apoptosis.
Gene_expression (expression) of TRPC6 in podocyte associated with apoptosis
2) Confidence 0.75 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.60 Pain Relevance 0.14
The data suggest that IL-1beta-induced dysregulation of Ca(2+) homeostasis is the result of enhanced ROCE and TRPC6 expression.
Gene_expression (expression) of TRPC6
3) Confidence 0.72 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17670890 Disease Relevance 0 Pain Relevance 0.09
By transfection with TRPC6 siRNA, Ang II-induced podocyte apoptosis and the transient Ca(2+) influx were inhibited.
Gene_expression (transfection) of TRPC6 in podocyte associated with apoptosis
4) Confidence 0.65 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.66 Pain Relevance 0.12
Only TRPC6 expression was in the same range in CNS as in peripheral tissues.
Gene_expression (expression) of TRPC6
5) Confidence 0.63 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.04
While not all of these proteins were specifically shown to be TRPC6 binding proteins in this publication, one of the authors reports that at least eight, Spna2, Spnb2, Myh9, Myh10, Actn1, Acnt4, Dbn1, Gsn, do also specifically co-IP with TRPC6 (W.P.
Gene_expression (proteins) of TRPC6
6) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.27 Pain Relevance 0
Cellular localization of TRPC3, TRPC5 and TRPC6 mRNAs
Gene_expression (mRNAs) of TRPC6
7) Confidence 0.55 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.16
For TRPC3, C5 and TRPC6 positive reactions were observed in the cytoplasm of neuronal cells in the C2 area of the hippocampus without any strong variation of expression levels (Fig. 4A).
Gene_expression (expression) of TRPC6 in neuronal associated with hippocampus
8) Confidence 0.55 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.15
On this basis, TRPC3 expression was higher in some tissues, e.g. in cerebrum, skeletal muscle and heart of C57Bl/10 mice while TRPC6 expression was lower in the same tissues (Fig. 5).
Gene_expression (expression) of TRPC6 in heart
9) Confidence 0.49 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.62 Pain Relevance 0.10
On this basis, TRPC3 expression was higher in some tissues, e.g. in cerebrum, skeletal muscle and heart of C57Bl/10 mice while TRPC6 expression was lower in the same tissues (Fig. 5).
Gene_expression (expression) of TRPC6 in cerebrum
10) Confidence 0.17 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.62 Pain Relevance 0.10
On this basis, TRPC3 expression was higher in some tissues, e.g. in cerebrum, skeletal muscle and heart of C57Bl/10 mice while TRPC6 expression was lower in the same tissues (Fig. 5).
Gene_expression (expression) of TRPC6 in skeletal muscle
11) Confidence 0.17 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.62 Pain Relevance 0.10
The expression of TRPV1, TRPC1, TRPC6, TRPM4, and TRPM5 is also increased in some cancers.
Gene_expression (expression) of TRPC6 associated with cancer
12) Confidence 0.10 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17616360 Disease Relevance 1.57 Pain Relevance 0.09

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