INT145129

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.91
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc6) plasma membrane (Trpc6) transmembrane transport (Trpc6)
Anatomy Link Frequency
podocyte 4
Trpc6 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 4 92.84 High High
Calcium channel 2 81.16 Quite High
TRP channel 1 75.00 Quite High
Cancer pain 2 53.84 Quite High
imagery 2 50.12 Quite High
cytokine 2 32.00 Quite Low
glial activation 2 28.80 Quite Low
Disease Link Frequency Relevance Heat
Melanoma 3 99.76 Very High Very High Very High
Cancer 9 99.64 Very High Very High Very High
Aggression 1 99.12 Very High Very High Very High
Apoptosis 21 98.72 Very High Very High Very High
Reprotox - General 1 4 94.88 High High
Death 1 60.56 Quite High
Necrosis 1 58.72 Quite High
Cancer Pain 2 53.84 Quite High
Metastasis 1 46.40 Quite Low
Pancreatic Cancer 1 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the enhancement expression of TRPC6 as well as the increased Ca(2+) influx mediated by TRPC6 channels contributed to the podocyte apoptosis.
Positive_regulation (enhancement) of Gene_expression (expression) of TRPC6 in podocyte associated with apoptosis
1) Confidence 0.67 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.65 Pain Relevance 0.09
The data suggest that IL-1beta-induced dysregulation of Ca(2+) homeostasis is the result of enhanced ROCE and TRPC6 expression.
Positive_regulation (result) of Gene_expression (expression) of TRPC6
2) Confidence 0.65 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17670890 Disease Relevance 0 Pain Relevance 0.12
By transfection with TRPC6 siRNA, Ang II-induced podocyte apoptosis and the transient Ca(2+) influx were inhibited.
Positive_regulation (transfection) of Gene_expression (transfection) of TRPC6 in podocyte associated with apoptosis
3) Confidence 0.49 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.66 Pain Relevance 0.12
The data suggest that IL-1beta-induced dysregulation of Ca(2+) homeostasis is the result of enhanced ROCE and TRPC6 expression.
Positive_regulation (enhanced) of Gene_expression (expression) of TRPC6
4) Confidence 0.44 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17670890 Disease Relevance 0 Pain Relevance 0.09
The expression of TRPV1, TRPC1, TRPC6, TRPM4, and TRPM5 is also increased in some cancers.
Positive_regulation (increased) of Gene_expression (expression) of TRPC6 associated with cancer
5) Confidence 0.09 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17616360 Disease Relevance 1.59 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox