INT14515

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Context Info
Confidence 0.28
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 8.51
Pain Relevance 0.97

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Anatomy Link Frequency
neuron 7
muscle 1
Lrrc23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 96.48 Very High Very High Very High
cva 1 90.44 High High
vincristine 1 88.80 High High
Inflammation 3 85.00 Quite High
Pain 2 84.32 Quite High
Catecholamine 1 83.16 Quite High
Angina 2 79.52 Quite High
Somatostatin 1 78.24 Quite High
headache 1 77.20 Quite High
abdominal pain 1 76.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 48 99.88 Very High Very High Very High
Abscess 5 94.20 High High
Necrosis 2 93.64 High High
Suppuration 1 93.60 High High
Oligodendroglioma 1 90.64 High High
Hemorrhage 1 90.44 High High
Recurrence 4 90.28 High High
Neurocytoma 5 89.92 High High
Solid Tumor 1 89.56 High High
Facial Paralysis 1 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoperoxidase staining showed that all tumors were positive for chromogranin and neuron-specific enolase.
Positive_regulation (positive) of neuron-specific enolase in neuron associated with cancer
1) Confidence 0.28 Published 1985 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 3907377 Disease Relevance 1.32 Pain Relevance 0.21
Immunohistochemical examination showed the tumor cells to be strongly positive for neuron-specific enolase, sparsely positive for S-100 protein, and negative for glial fibrillary acidic protein.
Positive_regulation (positive) of neuron-specific enolase in neuron associated with cancer
2) Confidence 0.15 Published 1990 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 1697045 Disease Relevance 1.05 Pain Relevance 0.08
Immunohistochemical studies demonstrated positive immunoreactivity for neuron-specific enolase, synaptophysin, chromogranin, vimentin, S-100 protein and p30-32 MIC-2 gene product.
Positive_regulation (immunoreactivity) of neuron-specific enolase in neuron
3) Confidence 0.15 Published 2005 Journal Acta Otolaryngol. Section Abstract Doc Link 15823816 Disease Relevance 0.74 Pain Relevance 0.13
Immunohistochemically, strong reactions for S-100 protein and neuron-specific enolase were observed in the cytoplasm of spindle cells, whereas reactions for muscle actin and desmin were negative.
Positive_regulation (reactions) of neuron-specific enolase in muscle
4) Confidence 0.11 Published 1994 Journal Pathol. Int. Section Abstract Doc Link 8055113 Disease Relevance 0.98 Pain Relevance 0.12
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Positive_regulation (positive) of neuron-specific enolase in neuron associated with cancer
5) Confidence 0.10 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.98 Pain Relevance 0.08
Tumor cells showed positive staining for vimentin and neuron-specific enolase but were negative for desmin, alpha-smooth muscle actin, and S-100 protein.
Positive_regulation (staining) of neuron-specific enolase in neuron associated with cancer
6) Confidence 0.06 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9252861 Disease Relevance 1.90 Pain Relevance 0.08
Immunohistochemical examination showed proliferating spindle cells, which were positive for vimentin and smooth muscle actin, but negative for desmin, CD34, cytokeratin, epithelial membrane antigen, S100 protein, and neuron specific enolase.
Positive_regulation (negative) of neuron specific enolase in neuron
7) Confidence 0.03 Published 2007 Journal Surg. Today Section Abstract Doc Link 17243033 Disease Relevance 0.79 Pain Relevance 0.19
Immunohistochemically, the ovoid cells were positive for neuron-specific enolase, S-100, CAM5.2, Leu7, and chromogranin A, and negative for carcinoembryonic antigen and epithelial membrane antigen.
Positive_regulation (positive) of neuron-specific enolase in neuron
8) Confidence 0.03 Published 1999 Journal Surg. Today Section Abstract Doc Link 10552341 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

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