INT145152

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.45
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGF, EGFR) signal transduction (EGF, EGFR) extracellular region (EGF, EGFR)
plasma membrane (EGF, EGFR) endosome (EGFR) cell morphogenesis (EGFR)
Anatomy Link Frequency
Gill 1
EGF (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 2 95.44 Very High Very High Very High
adenocard 1 41.92 Quite Low
Angina 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 6 98.84 Very High Very High Very High
Cancer 27 98.56 Very High Very High Very High
Apoptosis 1 96.64 Very High Very High Very High
Head & Neck Cancer 1 96.08 Very High Very High Very High
Disease 15 95.44 Very High Very High Very High
Ulcers 2 95.12 Very High Very High Very High
Gastritis 6 94.56 High High
Infection 2 92.16 High High
Metastasis 2 80.04 Quite High
Colon Cancer 1 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cetuximab competitively blocks the binding of the EGF and other ligands to the EGFR thus preventing the activation of the downstream TK resulting in growth arrest and apoptosis (Gill et al 1984; Sato et al 1983; Baselga 2000).
EGF Binding (binding) of EGFR in Gill associated with apoptosis
1) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.50 Pain Relevance 0
Binding of epidermal growth factor (EGF) to its receptor (EGFR) may be important in the development of gastric cancer.
EGF Binding (Binding) of EGFR associated with stomach cancer
2) Confidence 0.10 Published 2007 Journal Am. J. Gastroenterol. Section Abstract Doc Link 17617207 Disease Relevance 0.91 Pain Relevance 0.10
Binding of epidermal growth factor (EGF) to its receptor (EGFR) may be important in the development of gastric cancer.
epidermal growth factor Binding (Binding) of EGFR associated with stomach cancer
3) Confidence 0.10 Published 2007 Journal Am. J. Gastroenterol. Section Abstract Doc Link 17617207 Disease Relevance 0.91 Pain Relevance 0.10
NRG2, which encodes neuregulin-2, is a member of the epidermal growth factor (EGF) family and binds to ErbB receptors.
EGF Binding (binds) of ErbB
4) Confidence 0.06 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.12 Pain Relevance 0

General Comments

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