INT145163

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nsfl1c) intracellular (Tlr4) cytoplasm (Tlr4)
cytosol (Nsfl1c) lipid binding (Nsfl1c) signal transduction (Tlr4)
Anatomy Link Frequency
dopaminergic neurons 2
Tlr4 (Mus musculus)
Nsfl1c (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 97.64 Very High Very High Very High
Inflammatory mediators 1 91.56 High High
Inflammation 1 86.56 High High
agonist 1 75.48 Quite High
opioid receptor 4 75.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.36 Very High Very High Very High
INFLAMMATION 2 91.16 High High
Drug Induced Neurotoxicity 2 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistic studies showed that both l- and d- morphine failed to protect dopaminergic neurons in cultures from NADPH oxidase (PHOX) knockout mice and significantly reduced LPS-induced PHOX cytosolic subunit p47(phox) translocation to the cell membrane by inhibiting ERK phosphorylation.
LPS Positive_regulation (induced) of Localization (translocation) of p47 in dopaminergic neurons associated with targeted disruption and morphine
1) Confidence 0.02 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17617613 Disease Relevance 0.43 Pain Relevance 0.94

General Comments

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