INT145176

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
cleavage 2
pigmentation 2
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 80.04 Quite High
antinociception 27 62.92 Quite High
Analgesic 38 50.00 Quite Low
Morphine 14 49.16 Quite Low
analgesia 20 47.72 Quite Low
electroacupuncture 1 45.92 Quite Low
Nucleus accumbens 2 42.52 Quite Low
Pain threshold 3 36.32 Quite Low
Antinociceptive 21 18.32 Low Low
antagonist 7 15.40 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 97.60 Very High Very High Very High
Pain 14 36.32 Quite Low
Nociception 5 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice.
Positive_regulation (pigmentation) of Gene_expression (expression) of tyrosinase in pigmentation
1) Confidence 0.48 Published 2009 Journal Pigment Cell Melanoma Res Section Title Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.08
These data demonstrate that pTT treatment increases eumelanogenesis in HFs, associated with increased tyrosinase, TRP-1 and MC-1R expression.
Positive_regulation (increased) of Gene_expression (expression) of tyrosinase
2) Confidence 0.36 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17620094 Disease Relevance 0 Pain Relevance 0.07
It was again verified that with ME as substrate, Bestatin inhibited the cleavage of the Tyr–Gly peptide bond depending on the observation of the reduced collection of Gly–Gly–Phe–Met, while there was no fall in the production of Tyr–Gly–Gly and Phe–Met and also an increase of Tyr–Gly–Gly.
Positive_regulation (increase) of Gene_expression (production) of Tyr in cleavage
3) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.12

General Comments

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