INT145183

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.51
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Efnb2) plasma membrane (Efnb2)
Anatomy Link Frequency
spinal nerve 2
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 20 100.00 Very High Very High Very High
allodynia 14 99.36 Very High Very High Very High
Spinal cord 60 98.08 Very High Very High Very High
Dorsal horn 22 97.32 Very High Very High Very High
Root ganglion neuron 6 93.64 High High
Hyperalgesia 22 87.76 High High
Neuropathic pain 20 83.52 Quite High
dorsal rhizotomy 2 82.00 Quite High
Inflammation 18 79.92 Quite High
Thermal hyperalgesia 26 69.36 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 14 100.00 Very High Very High Very High
Neuropathic Pain 38 99.36 Very High Very High Very High
Nervous System Injury 6 94.80 High High
Ganglion Cysts 10 93.32 High High
Hyperalgesia 50 87.76 High High
Nociception 28 86.00 High High
Injury 10 85.04 High High
INFLAMMATION 18 79.92 Quite High
Targeted Disruption 4 61.56 Quite High
Pain 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of ephrinB2 siRNA reduced the expression of ephrinB2 and mechanical allodynia.
Negative_regulation (reduced) of Gene_expression (expression) of ephrinB2
1) Confidence 0.17 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0 Pain Relevance 0
Administration of ephrinB2 siRNA decreased expression of ephrinB2 and mechanical allodynia after spinal nerve crush.
Negative_regulation (decreased) of Gene_expression (expression) of ephrinB2 in spinal nerve associated with allodynia
2) Confidence 0.03 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.93 Pain Relevance 0.90
Sequestration of ephrinB2 following chronic inflammatory pain in the cord prevents the rise in NR2B phosphorylation
Negative_regulation (prevents) of Gene_expression (Sequestration) of ephrinB2 associated with eae
3) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.58 Pain Relevance 0.41

General Comments

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