INT145185

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Ephb2) molecular_function (Ephb2) cellular_component (Ephb2)
biological_process (Ephb2)
Anatomy Link Frequency
hippocampus 1
Ephb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 3 96.96 Very High Very High Very High
nMDA receptor 28 96.36 Very High Very High Very High
Spinal cord 30 73.28 Quite High
Hippocampus 5 69.16 Quite High
Eae 10 67.12 Quite High
Neuropathic pain 11 50.00 Quite Low
Inflammation 9 50.00 Quite Low
Thermal hyperalgesia 13 37.88 Quite Low
intrathecal 16 33.28 Quite Low
neuralgia 3 10.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 87.28 High High
Congenital Anomalies 1 78.80 Quite High
Targeted Disruption 2 77.32 Quite High
Inflammatory Pain 7 67.12 Quite High
INFLAMMATION 9 50.00 Quite Low
Hyperalgesia 25 37.88 Quite Low
Nociception 14 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SUMMARY OF BACKGROUND DATA: It has been reported that EphB2 regulates the development of synaptic plasticity in the hippocampus by interacting with N-methyl-D-aspartate (NMDA) receptors.
EphB2 Binding (interacting) of in hippocampus
1) Confidence 0.28 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.09 Pain Relevance 0
They also showed that in HEK293T cells mutation of the Src-binding site on EphB2 or expression of a dominant negative of Fyn (inhibiting Src family kinases) disabled the phosphorylation of NR2B effect of ephrinB2 and the potentiation of NMDA receptor activity.
EphB2 Binding (binding) of associated with nmda receptor
2) Confidence 0.24 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.31

General Comments

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