INT145187

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 3.43
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Efnb2) plasma membrane (Efnb2)
Anatomy Link Frequency
spinal nerve 1
neurons 1
spinal cord 1
DRG 1
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 12 99.56 Very High Very High Very High
allodynia 28 99.36 Very High Very High Very High
Eae 40 99.24 Very High Very High Very High
Hyperalgesia 44 98.64 Very High Very High Very High
Inflammation 36 98.38 Very High Very High Very High
Spinal cord 120 97.68 Very High Very High Very High
Dorsal horn 44 96.92 Very High Very High Very High
Thermal hyperalgesia 52 93.08 High High
nMDA receptor 112 91.40 High High
Neuropathic pain 44 89.36 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 80 99.36 Very High Very High Very High
Ganglion Cysts 20 99.36 Very High Very High Very High
Inflammatory Pain 28 99.24 Very High Very High Very High
Hyperalgesia 100 98.64 Very High Very High Very High
INFLAMMATION 36 98.38 Very High Very High Very High
Nervous System Injury 12 98.04 Very High Very High Very High
Injury 20 85.04 High High
Pain 52 82.80 Quite High
Nociception 56 81.44 Quite High
Targeted Disruption 8 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that the expression of ephrinB2 was enhanced in neurons in DRG and spinal cord by the injury in a time-dependent manner.
Gene_expression (expression) of ephrinB2 in spinal cord
1) Confidence 0.22 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.05 Pain Relevance 0
Administration of ephrinB2 siRNA reduced the expression of ephrinB2 and mechanical allodynia.
Gene_expression (expression) of ephrinB2
2) Confidence 0.22 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0 Pain Relevance 0
Expression of ephrinB2 and EphB1 were examined by immunoblotting and immunohistochemical analyses with anti-EphB and anti-ephrinB antibodies.
Spec (examined) Gene_expression (Expression) of ephrinB2
3) Confidence 0.22 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.07 Pain Relevance 0
Results showed that the expression of ephrinB2 was enhanced in neurons in DRG and spinal cord by the injury in a time-dependent manner.
Gene_expression (expression) of ephrinB2 in DRG
4) Confidence 0.08 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.05 Pain Relevance 0
Administration of ephrinB2 siRNA decreased expression of ephrinB2 and mechanical allodynia after spinal nerve crush.
Gene_expression (expression) of ephrinB2 in spinal nerve associated with allodynia
5) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.93 Pain Relevance 0.90
The mechanism we proposed for a physiological role of ephrinB2 in inflammatory hyperalgesia and allodynia (Battaglia et al., 2003) was a rapid increase in the expression of ephrinB2 in the presynaptic membrane, with consequent clustering and activation of EphB receptors postsynaptically.
Gene_expression (expression) of ephrinB2 associated with hyperalgesia, allodynia and inflammation
6) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.03 Pain Relevance 0.88
Kobayashi et al. (2007) found that expression of ephrinB2 in dorsal root ganglion neurons was enhanced by nerve injury, and EphB1 receptor expression was observed in the dorsal horn of the spinal cord of adult rat.
Gene_expression (expression) of ephrinB2 in neurons associated with ganglion cysts, nervous system injury, dorsal horn, root ganglion neuron and spinal cord
7) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.74 Pain Relevance 0.77
Sequestration of ephrinB2 following chronic inflammatory pain in the cord prevents the rise in NR2B phosphorylation
Gene_expression (Sequestration) of ephrinB2 associated with eae
8) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.56 Pain Relevance 0.38

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