INT145188

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 6.07
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Anatomy Link Frequency
DRG 3
dorsal 1
Efnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 15 99.14 Very High Very High Very High
Spinal cord 84 98.96 Very High Very High Very High
dorsal root ganglion 32 98.92 Very High Very High Very High
Eae 38 98.72 Very High Very High Very High
allodynia 14 97.64 Very High Very High Very High
Sciatic nerve 3 97.08 Very High Very High Very High
dorsal rhizotomy 26 96.36 Very High Very High Very High
Neuropathic pain 23 96.00 Very High Very High Very High
Thermal hyperalgesia 29 94.56 High High
Dorsal horn 22 92.68 High High
Disease Link Frequency Relevance Heat
Pain 29 99.14 Very High Very High Very High
Ganglion Cysts 40 98.92 Very High Very High Very High
Injury 28 97.88 Very High Very High Very High
Neuropathic Pain 41 97.64 Very High Very High Very High
Hyperalgesia 53 94.56 High High
Nervous System Injury 12 90.16 High High
INFLAMMATION 18 85.40 High High
Nociception 31 73.20 Quite High
Targeted Disruption 4 56.92 Quite High
Inflammatory Pain 14 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot and immunobiochemistry analysis and immunofluorescence staining techniques were used to detect the expression and location of the ephrinB-EphB receptor proteins in DRG and SC.
Gene_expression (expression) of ephrinB in DRG associated with dorsal root ganglion and spinal cord
1) Confidence 0.32 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.47 Pain Relevance 1.50
The results showed that expression of ephrinB1 and EphB1 receptor proteins was significantly upregulated in DRG and SC in a time-dependent manner corresponding to the development of thermal hyperalgesia after CCI.
Gene_expression (expression) of ephrinB1 in DRG associated with dorsal root ganglion, eae, thermal hyperalgesia and spinal cord
2) Confidence 0.32 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.52 Pain Relevance 1.60
The present study investigated the correlation between expression of ephrinB and EphB receptor proteins and chronic constriction injury (CCI) of the sciatic nerve and dorsal rhizotomy (DR) in dorsal root ganglion (DRG) and spinal cord (SC); and interaction of CCI and DR on expression of these signals.
Gene_expression (expression) of ephrinB in DRG associated with ganglion cysts, dorsal root ganglion, dorsal rhizotomy, eae, injury, sciatic nerve and spinal cord
3) Confidence 0.32 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 0.86 Pain Relevance 0.90
OBJECTIVE: Using immunoblotting, immunohistochemistry, and RNA interference techniques, we examined the expression levels of EphB receptors and ephrinB ligands in neuropathic pain.
Spec (examined) Gene_expression (expression) of ephrinB
4) Confidence 0.04 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.10 Pain Relevance 0
Song et al. (2008a) studied the expression of ephrinB1 and EphB1 in the dorsal root ganglia and spinal cord after chronic constriction injury (a model of neuropathic pain), dorsal rhizotomy or a combination of both.
Gene_expression (expression) of ephrinB1 in dorsal associated with dorsal rhizotomy, eae, injury, neuropathic pain and spinal cord
5) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.95 Pain Relevance 0.91
The study by Kobayashi et al. (2007) and Song et al. (2008a,b) would suggest that in more chronic forms of pain this may be accompanied by an increase in synthesis of the ephrinB molecule.
Gene_expression (synthesis) of ephrinB associated with pain
6) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.17 Pain Relevance 0.83

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