INT145190

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Efnb2) plasma membrane (Efnb2)
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 56 98.72 Very High Very High Very High
Spinal cord 60 94.72 High High
Hippocampus 10 72.44 Quite High
Neuropathic pain 20 50.00 Quite Low
Inflammation 18 50.00 Quite Low
Dorsal horn 22 20.08 Low Low
neuralgia 3 10.00 Low Low
intrathecal 32 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 26 5.00 Very Low Very Low Very Low
Hyperalgesia 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 28 99.98 Very High Very High Very High
Neuropathic Pain 38 50.00 Quite Low
INFLAMMATION 18 50.00 Quite Low
Hyperalgesia 50 5.00 Very Low Very Low Very Low
Pain 26 5.00 Very Low Very Low Very Low
Inflammatory Pain 14 5.00 Very Low Very Low Very Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that induction of ephrinB2 might activate EphB1/ephrinB2 signaling pathway to regulate synaptic plasticity and reorganization, and that ephrinB2 siRNA could be a potential therapeutic agent for neuropathic pain.


Positive_regulation (induction) of ephrinB2
1) Confidence 0.20 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0 Pain Relevance 0
The pro-nociceptive effects of ephrinB2 are mediated by Src-family kinases
Positive_regulation (effects) of ephrinB2 associated with nociception
2) Confidence 0.03 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.10 Pain Relevance 0.16
Furthermore, here we have shown that the Src-family kinase inhibitor PP2 could prevent ephrinB2 induction of NR2B phosphorylation.
Positive_regulation (induction) of ephrinB2
3) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.08 Pain Relevance 0.16

General Comments

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