INT145201

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rab38) vesicle-mediated transport (Rab38) Golgi apparatus (Rab38)
endoplasmic reticulum (Rab38) GTPase activity (Rab38) cytoplasm (Rab38)
Anatomy Link Frequency
brain 2
amygdala 2
Rab38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 4 98.60 Very High Very High Very High
cocaine 30 98.52 Very High Very High Very High
withdrawal 6 88.64 High High
Kappa opioid receptor 4 80.80 Quite High
Opioid 4 64.44 Quite High
addiction 2 56.32 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed lowering in KOP-r binding, which was shown in two brain regions of cocaine withdrawn animals, might contribute to the persistent dysphoria reported a long time after the discontinuation of the drug.
Negative_regulation (lowering) of KOP-r Binding (binding) of in brain associated with cocaine
1) Confidence 0.37 Published 2007 Journal Synapse Section Abstract Doc Link 17621646 Disease Relevance 0 Pain Relevance 0.62
In contrast, there was a decrease in KOP-r binding in the septum and the basolateral amygdala of rats withdrawn for 14 days from chronic escalating dose binge cocaine administration, compared to rats at the end of 14 days chronic escalating dose cocaine administration.
Negative_regulation (decrease) of KOP-r Binding (binding) of in amygdala associated with amygdala and cocaine
2) Confidence 0.37 Published 2007 Journal Synapse Section Abstract Doc Link 17621646 Disease Relevance 0.06 Pain Relevance 0.99

General Comments

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