INT145221

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.59
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
Langerhans cell 2
nerve 1
apoptotic cell 1
Tp53 (Rattus norvegicus)
Tp53 - R72P (1)
Pain Link Frequency Relevance Heat
cINOD 12 100.00 Very High Very High Very High
rheumatoid arthritis 32 93.64 High High
ischemia 37 93.44 High High
Spinal cord 8 83.72 Quite High
Inflammation 50 78.80 Quite High
Arthritis 118 63.84 Quite High
cva 10 55.64 Quite High
cytokine 8 46.80 Quite Low
Paracetamol 28 5.00 Very Low Very Low Very Low
alcohol 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 112 100.00 Very High Very High Very High
INFLAMMATION 79 100.00 Very High Very High Very High
Colon Cancer 22 100.00 Very High Very High Very High
Apoptosis 221 99.48 Very High Very High Very High
Hypoxia 15 99.16 Very High Very High Very High
Death 49 98.88 Very High Very High Very High
Nervous System Injury 2 98.60 Very High Very High Very High
Injury 68 98.28 Very High Very High Very High
Rheumatoid Arthritis 32 93.64 High High
Cv Unclassified Under Development 13 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After protein extraction in lysis buffer, equal amounts of

protein samples from lysates were pooled and examined by Western bolt analysis using anti-p53 monoclonal antibody D07, which recognizes wild-type and mutant p53 from rodents and humans.

p53 Binding (recognizes) of
1) Confidence 0.37 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.80 Pain Relevance 0.20
After protein extraction in lysis buffer, equal amounts of

protein samples from lysates were pooled and examined by Western bolt analysis using anti-p53 monoclonal antibody D07, which recognizes wild-type and mutant p53 from rodents and humans.

p53 Binding (recognizes) of
2) Confidence 0.37 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.81 Pain Relevance 0.21
Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).


Tumor protein p53 Binding (interactions) of in Langerhans cell associated with cancer
3) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.36 Pain Relevance 0
Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).


Tumor protein p53 Binding (binding) of in Langerhans cell associated with cancer
4) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.36 Pain Relevance 0
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
TP53 (R72P) Binding (association) of associated with inflammation, colon cancer and cinod
5) Confidence 0.20 Published 2007 Journal Pharmacogenet. Genomics Section Abstract Doc Link 17622940 Disease Relevance 0.89 Pain Relevance 0.35
Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction?
TP53 Binding (interaction) of associated with inflammation, colon cancer and cinod
6) Confidence 0.17 Published 2007 Journal Pharmacogenet. Genomics Section Title Doc Link 17622940 Disease Relevance 0.75 Pain Relevance 0.36
to bind to p53 in order to stabilize it, and also activates the expression of various genes including Bax (a proapoptotic member of the Bcl-2 family) [25].
p53 Binding (bind) of
7) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.18 Pain Relevance 0.07
So far, we have no
               direct evidence showing that p53 and WOX1 physically interact during peripheral
               nerve injury. 
p53 Binding (interact) of in nerve associated with nervous system injury
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.68 Pain Relevance 0.04
Several studies have shown that IGF-1 suppresses the action of p53 that is phosphorylated and stabilized when defects are found in DNA.
p53 Binding (action) of
9) Confidence 0.06 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.48 Pain Relevance 0
combining with p53 may promote apoptotic cell death in ischemic areas [22].
p53 Binding (combining) of in apoptotic cell associated with apoptosis and death
10) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.70 Pain Relevance 0.13
In the case of relatively mild DNA damage, PARP-1 activation enhances DNA repair by interacting with p53 protein, signaling cell-cycle arrest, and facilitating DNA repair enzymes, including XRCC1 and DNA-dependent protein kinases to access damaged DNA [70].
p53 Binding (interacting) of
11) Confidence 0.05 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.58 Pain Relevance 0

General Comments

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