INT145237

Context Info Confidence 0.78 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 1.71

signal transduction (CHRND) transport (CHRND) plasma membrane (CHRND)

Anatomy Link Frequency blood 1 immune cells 1 CHRND (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 18 89.36 Nicotine 18 88.68 antagonist 3 87.72 agonist 3 63.48 cocaine 3 46.04 alcohol 3 45.56

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PMN nicotinic receptor gene expression was present and contained numerous variants (eight).

Gene_expression (expression) of PMN nicotinic receptor gene

1) Confidence 0.78 Published 2007 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17624236 Disease Relevance 0 Pain Relevance 0.61

The number of variants suggests that indeed a novel nicotinic receptor may be mediating this effect, while simultaneously demonstrating the significance of the cholinergic receptor expression in these immune cells.

Gene_expression (expression) of cholinergic receptor in immune cells

2) Confidence 0.78 Published 2007 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17624236 Disease Relevance 0 Pain Relevance 0.49

Human leukocyte total RNA isolated from whole blood were analyzed, using the Human Genome Survey microarray (Applied Biosystems), for cholinergic receptor expression.

Spec (analyzed) Gene_expression (expression) of cholinergic receptor in blood

3) Confidence 0.78 Published 2007 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17624236 Disease Relevance 0 Pain Relevance 0.62

General Comments

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