INT145266

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 154
Total Number 157
Disease Relevance 109.83
Pain Relevance 45.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A) cell death (IL17A) extracellular region (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
T cells 30
lymphocytes 11
Th17 cells 10
neutrophils 4
joint 3
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 3435 100.00 Very High Very High Very High
Inflammation 2889 100.00 Very High Very High Very High
cytokine 2746 100.00 Very High Very High Very High
Osteoarthritis 419 100.00 Very High Very High Very High
methotrexate 371 99.98 Very High Very High Very High
chemokine 461 99.88 Very High Very High Very High
Arthritis 2725 99.84 Very High Very High Very High
corticosteroid 103 99.82 Very High Very High Very High
Central nervous system 79 99.70 Very High Very High Very High
headache 27 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 5418 100.00 Very High Very High Very High
INFLAMMATION 3071 100.00 Very High Very High Very High
Knee Osteoarthritis 67 100.00 Very High Very High Very High
Keloid Scars 1856 99.84 Very High Very High Very High
Cancer 853 99.80 Very High Very High Very High
Vasculitis 136 99.70 Very High Very High Very High
Disease 2635 99.68 Very High Very High Very High
Osteoarthritis 325 99.68 Very High Very High Very High
Severe Combined Immunodeficiency 7 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 165 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it remains also unanswered whether TH17 cells are the only source of IL-17s within the processes leading to airway neutrophilia in asthmatic lungs since CD11b+/F4/80+ alveolar macrophages are also capable of producing considerable amounts of IL-17A as demonstrated in a mouse model of experimental asthma [87].
Gene_expression (source) of IL-17 in alveolar macrophages associated with asthma
1) Confidence 0.75 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.77 Pain Relevance 0.04
In addition, Th17 cells are known to be important for the promotion of neutrophil-mediated inflammation by producing IL-17A, a cytokine known to indirectly activate neutrophil chemotaxis and extend their survival [10,22].
Gene_expression (producing) of IL-17A in neutrophil associated with inflammation and cytokine
2) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.61 Pain Relevance 0.69
T helper 17 (Th17) cells have also been proposed to have a relevant role in the early phase of RA through the production of IL-17 [7,8].
Gene_expression (production) of IL-17 associated with rheumatoid arthritis
3) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.23 Pain Relevance 0.71
Therefore, we analyzed IL-17A levels in these patients since it has already been described that this cytokine is important for the survival of neutrophils [22].
Spec (analyzed) Gene_expression (levels) of IL-17A in neutrophils associated with cytokine
4) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.53 Pain Relevance 0.88
In addition, we have previously proposed a mechanism for generation of Th17 cells in the joint itself, as cell contact with in vitro (LPS) activated [36] or in vivo activated monocytes from inflamed joints from RA patients [11] leads to induction of IL-17 production in memory CD4+ T cells, suggesting that newly recruited CD4+ T cells can be skewed toward a Th17 phenotype at the site of inflammation.
Gene_expression (production) of IL-17 in Th17 cells associated with inflammation and arthritis
5) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.65 Pain Relevance 0.26
These findings suggest a relationship between local IL-17 expression and active synovitis.
Gene_expression (expression) of IL-17 associated with synovitis
6) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.36 Pain Relevance 0.08
Both synovial tissue IL-17 mRNA expression and persistent PDUS signal have been independently associated with increased joint damage progression in RA [18], [19], [23].
Gene_expression (expression) of IL-17 mRNA in joint associated with arthritis
7) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.98 Pain Relevance 0.38
Intracellular expression of IL-17, IFN?
Gene_expression (expression) of IL-17
8) Confidence 0.71 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2931706 Disease Relevance 0.73 Pain Relevance 0.30
In addition, Stamp et al did not detect IL-17 production by other cell types [12].
Gene_expression (production) of IL-17
9) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 1.11 Pain Relevance 0.40
We then assessed if the presence of CD4+ T cells expressing IL-17, IFN?
Gene_expression (expressing) of IL-17 in T cells
10) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.57 Pain Relevance 0.26
Our demonstration that the local presence of IL-17 producing CD4+ T cells (either Th17 or IL-17+IFN?
Gene_expression (producing) of IL-17 in T cells
11) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.95 Pain Relevance 0.40
A role for IL-17 in angiogenesis is supported by the recent findings that local overexpression of IL-17 in C57BL/6 mice induces arthritis with increased vascularity, and that IL-17 induces migration of endothelial cells in vitro, along with increased angiogenesis in Matrigel plugs [34].
Gene_expression (overexpression) of IL-17 in endothelial cells associated with arthritis
12) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.81 Pain Relevance 0.35
Our demonstration that the local presence of IL-17 producing CD4+ T cells (either Th17 or IL-17+IFN?
Gene_expression (producing) of IL-17 in T cells
13) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.94 Pain Relevance 0.39
To demonstrate a causal relationship between the presence of IL-17 producing cells within the joint and VEGF-A production, we cultured synovial fibroblasts (a known source of VEGF-A [26]) from 6 patients with RA with rIL-17 and measured secreted VEGF-A (Fig. 5D).
Gene_expression (producing) of IL-17 in joint associated with arthritis
14) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.59 Pain Relevance 0.23
Through their production of IL-17 and TNF?
Gene_expression (production) of IL-17
15) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.84 Pain Relevance 0.35
Of note, in our studies, the vast majority of cells producing IL-17 in PB, SF or ST were T cells (% CD3+ mean ± SD in PB 95±4.5; SF 95±4.5; ST 95.6±7.8%, Fig. 3).


Gene_expression (producing) of IL-17 in T cells
16) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.32 Pain Relevance 0.07
Bone and synovial explants from RA joints exhibit increased production of functional IL-17 compared to OA joints [10], and IL-17+ CD4+ T cells can be found in RA synovial tissue [11], [12].
Gene_expression (production) of IL-17 in joints associated with arthritis
17) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 1.14 Pain Relevance 0.76
The secretion of IL-17 by PBT and LPT was determined using an IL-17A specific ELISA (eBioscience).
Gene_expression (using) of IL-17
18) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.22
The IL-17 levels were significantly higher in scrub typhus patients than in the healthy group.
Gene_expression (levels) of IL-17 associated with rickettsiaceae infection
19) Confidence 0.65 Published 2010 Journal Vector Borne Zoonotic Dis. Section Abstract Doc Link 19485773 Disease Relevance 1.64 Pain Relevance 0.32
The IL-17 level in patients with headaches was higher than in patients without headaches, showing a borderline significance.
Gene_expression (level) of IL-17 associated with headache
20) Confidence 0.65 Published 2010 Journal Vector Borne Zoonotic Dis. Section Abstract Doc Link 19485773 Disease Relevance 1.31 Pain Relevance 0.45

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