INT145270

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.87
Pain Relevance 2.69

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transport (ABCG2) ATPase activity (ABCG2) plasma membrane (ABCG2)
transmembrane transport (ABCG2)
Anatomy Link Frequency
neural 2
intestine 2
livers 1
epithelial cells 1
stem cells 1
ABCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 35 99.80 Very High Very High Very High
Paracetamol 28 99.16 Very High Very High Very High
dexamethasone 14 95.76 Very High Very High Very High
Versed 4 93.44 High High
Morphine 3 90.52 High High
Central nervous system 33 87.44 High High
carbamazepine 2 85.68 High High
Bioavailability 6 71.56 Quite High
COX-2 inhibitor 104 69.60 Quite High
Spinal cord 9 67.04 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 23 100.00 Very High Very High Very High
INFLAMMATION 62 99.68 Very High Very High Very High
Cancer 377 99.66 Very High Very High Very High
Biliary Liver Cirrhosis 16 99.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 99.26 Very High Very High Very High
Overdose 6 98.96 Very High Very High Very High
Disease 33 98.64 Very High Very High Very High
Apoptosis 304 96.26 Very High Very High Very High
Hepatocellular Cancer 55 94.48 High High
Neurodegenerative Disease 23 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Gene_expression (expression) of BCRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
1) Confidence 0.75 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.82 Pain Relevance 0.44
The expression levels of mRNAs of efflux transporters analyzed by real-time RT-PCR indicated that mRNA expression levels of MDR1, MRP2, and BCRP in monkey intestine were significantly higher than those in human intestine.
Gene_expression (expression) of BCRP in intestine
2) Confidence 0.75 Published 2008 Journal Mol. Pharm. Section Abstract Doc Link 18247527 Disease Relevance 0 Pain Relevance 0.38
Furthermore, the expression of a variety of drug transporters (ABCB1, ABCG2, ABCC1-5) as well as the human transferrin receptor was demonstrated on the mRNA level.
Gene_expression (expression) of ABCG2
3) Confidence 0.75 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.14
In addition, the expression of DeltaNp63, ABCG2 (both putative positive LSC markers) and cytokeratin K3 (marker of corneal differentiation) were assessed using quantitative reverse transcription PCR (RT-PCR).
Gene_expression (expression) of ABCG2
4) Confidence 0.71 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0
This resistance is mediated by many mechanisms including over-expression of proteins involved in inhibition of apoptosis (i.e, Bcl-2), leading to insensitivity of tumor cells to apoptotic stimuli; an up-regulation of DNA repair; alteration of the target; up-regulation of detoxification enzymes (i.e., Glutathione S-transferases); and extrusion of chemotherapeutic drugs by overexpression of ATP-binding cassette family proteins, such as MRP (multidrug resistant-associated protein) BCRP (breast cancer resistance protein or mitoxantrone resistance protein) because these proteins regulate absorption, distribution, and excretion of various pharmacologic compounds [141].
Gene_expression (overexpression) of breast cancer resistance protein associated with cancer, breast cancer and apoptosis
5) Confidence 0.65 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.95 Pain Relevance 0.09
Quantitative RT-PCR revealed that the expression of the positive putative LSC markers DeltaNp63 and ABCG2 also showed a steady decrease in the zones furthest from the explant (p < 0.05 and p < 0.005, respectively).
Gene_expression (expression) of ABCG2
6) Confidence 0.62 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0
The expression levels of mRNAs of efflux transporters analyzed by real-time RT-PCR indicated that mRNA expression levels of MDR1, MRP2, and BCRP in monkey intestine were significantly higher than those in human intestine.
Gene_expression (levels) of BCRP in intestine
7) Confidence 0.58 Published 2008 Journal Mol. Pharm. Section Abstract Doc Link 18247527 Disease Relevance 0 Pain Relevance 0.38
P-glycoprotein (Pgp), multidrug resistance proteins (MRPs) and breast cancer resistance protein (BCRP) [45,48,50-53], that are overexpressed by the endothelial or epithelial cells of these barriers [52].
Gene_expression (overexpressed) of breast cancer resistance protein in epithelial cells associated with breast cancer
8) Confidence 0.58 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.17 Pain Relevance 0.22
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Gene_expression (levels) of BCRP associated with biliary liver cirrhosis and disease
9) Confidence 0.58 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.35 Pain Relevance 0.57
ABCB1, ABCG2 and transferrin receptor proteins were detected and functional activity of ABCB1, ABCG2 and the ABCC family was quantified in efflux experiments.
Gene_expression (detected) of ABCG2
10) Confidence 0.58 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.13
In the present study, B10 as a clonal cell line originated from a single human MSC, expresses Oct-4 and ABCG2 as general markers for stem cells, nestin as a neural stem cell marker, and Mash-1 and Otx-2 which are basic helix-loop-helix (bHLH) transcription factors important in developmental process of neurogenesis.
Gene_expression (expresses) of ABCG2 in neural associated with neurodegenerative disease
11) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.09 Pain Relevance 0
Both primary MSCs and B10 cells expressed ABCG2 [38] as a novel stem cell marker, nestin [39] and Musashi1 [40] both cell type-specific markers for neural stem cells (Figure 3A) before and after bFGF treatment.


Gene_expression (expressed) of ABCG2 in stem cells
12) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0
Both primary MSCs and B10 cells express Oct-4, which is a cell type-specific marker for the pluripotent stem cells [37] and B10 cells expressed ABCG2 [38] as a novel stem cell marker, nestin [39] and Musashi1 [40], both cell type-specific markers for neural stem cells before and after bFGF treatment (Figure 3).
Gene_expression (expressed) of ABCG2 in neural
13) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.22 Pain Relevance 0.03
It was reported that cancer cell lines that expresses ABCG2 was found to efflux some of the chlorophyll based photosensitizers and thus may confer resistance to this treatment modality [27,28].
Gene_expression (expresses) of ABCG2 associated with cancer
14) Confidence 0.36 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2212622 Disease Relevance 1.13 Pain Relevance 0
It is hypothesized that anti-inflammatory drugs regulate breast cancer resistance protein (BCRP) expression.
Gene_expression (expression) of breast cancer resistance protein associated with inflammation, breast cancer and cinod
15) Confidence 0.10 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.22
This resistance is mediated by many mechanisms including over-expression of proteins involved in inhibition of apoptosis (i.e, Bcl-2), leading to insensitivity of tumor cells to apoptotic stimuli; an up-regulation of DNA repair; alteration of the target; up-regulation of detoxification enzymes (i.e., Glutathione S-transferases); and extrusion of chemotherapeutic drugs by overexpression of ATP-binding cassette family proteins, such as MRP (multidrug resistant-associated protein) BCRP (breast cancer resistance protein or mitoxantrone resistance protein) because these proteins regulate absorption, distribution, and excretion of various pharmacologic compounds [141].
Gene_expression (overexpression) of mitoxantrone resistance protein associated with cancer, breast cancer and apoptosis
16) Confidence 0.09 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.96 Pain Relevance 0.09
Moreover, it has been verified that normal HSCs (or 'oval cells') in rodents also express the side population phenotype defined by high expression of ABC transporter [18,19].
Gene_expression (expression) of ABC transporter
17) Confidence 0.02 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 1.14 Pain Relevance 0
We observed a high diversity among CgPDR1 alleles and identified 57 distinct single amino acid substitutions, which may confer hyperactivity to CgPdr1p in order to mediate high expression of ABC transporter genes.
Gene_expression (expression) of ABC transporter associated with attention deficit hyperactivity disorder
18) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.33 Pain Relevance 0
Gain of function (GOF) mutations in CgPDR1 result in high ABC transporter expression.
Gene_expression (expression) of ABC transporter
19) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.36 Pain Relevance 0

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