INT145271

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.97
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCG2) ATPase activity (ABCG2) plasma membrane (ABCG2)
transmembrane transport (ABCG2)
ABCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 96.12 Very High Very High Very High
Versed 2 93.44 High High
Morphine 1 90.52 High High
COX-2 inhibitor 104 69.60 Quite High
Bile 3 61.04 Quite High
Inflammation 52 14.80 Low Low
cINOD 34 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 11 100.00 Very High Very High Very High
Disease 21 99.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 99.52 Very High Very High Very High
Biliary Liver Cirrhosis 8 99.32 Very High Very High Very High
Overdose 3 96.48 Very High Very High Very High
Apoptosis 302 96.26 Very High Very High Very High
Cancer 252 95.88 Very High Very High Very High
Sprains And Strains 112 89.60 High High
Fungal Infection 12 76.60 Quite High
Infection 28 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This resistance is mediated by many mechanisms including over-expression of proteins involved in inhibition of apoptosis (i.e, Bcl-2), leading to insensitivity of tumor cells to apoptotic stimuli; an up-regulation of DNA repair; alteration of the target; up-regulation of detoxification enzymes (i.e., Glutathione S-transferases); and extrusion of chemotherapeutic drugs by overexpression of ATP-binding cassette family proteins, such as MRP (multidrug resistant-associated protein) BCRP (breast cancer resistance protein or mitoxantrone resistance protein) because these proteins regulate absorption, distribution, and excretion of various pharmacologic compounds [141].
Positive_regulation (overexpression) of Gene_expression (overexpression) of breast cancer resistance protein associated with cancer, breast cancer and apoptosis
1) Confidence 0.49 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.95 Pain Relevance 0.09
Furthermore, the expression of a variety of drug transporters (ABCB1, ABCG2, ABCC1-5) as well as the human transferrin receptor was demonstrated on the mRNA level.
Positive_regulation (demonstrated) of Gene_expression (expression) of ABCG2
2) Confidence 0.48 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.14
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Positive_regulation (increased) of Gene_expression (levels) of BCRP associated with biliary liver cirrhosis and disease
3) Confidence 0.45 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.36 Pain Relevance 0.57
This resistance is mediated by many mechanisms including over-expression of proteins involved in inhibition of apoptosis (i.e, Bcl-2), leading to insensitivity of tumor cells to apoptotic stimuli; an up-regulation of DNA repair; alteration of the target; up-regulation of detoxification enzymes (i.e., Glutathione S-transferases); and extrusion of chemotherapeutic drugs by overexpression of ATP-binding cassette family proteins, such as MRP (multidrug resistant-associated protein) BCRP (breast cancer resistance protein or mitoxantrone resistance protein) because these proteins regulate absorption, distribution, and excretion of various pharmacologic compounds [141].
Positive_regulation (overexpression) of Gene_expression (overexpression) of mitoxantrone resistance protein associated with cancer, breast cancer and apoptosis
4) Confidence 0.07 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.96 Pain Relevance 0.09
We observed a high diversity among CgPDR1 alleles and identified 57 distinct single amino acid substitutions, which may confer hyperactivity to CgPdr1p in order to mediate high expression of ABC transporter genes.
Positive_regulation (mediate) of Gene_expression (expression) of ABC transporter associated with attention deficit hyperactivity disorder
5) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.33 Pain Relevance 0
Gain of function (GOF) mutations in CgPDR1 result in high ABC transporter expression.
Positive_regulation (result) of Gene_expression (expression) of ABC transporter
6) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.37 Pain Relevance 0

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